anti-Glycyl-tRNA Synthetase (GARS) Antikörper

Bezeichnung:: anti-Glycyl-tRNA Synthetase Antikörper (GARS)

Auf www.antikoerper-online.de finden Sie aktuell 68 Glycyl-tRNA Synthetase (GARS) Antikörper von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Glycyl-tRNA Synthetase Kits (19) und Glycyl-tRNA Synthetase Proteine (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 102 Glycyl-tRNA Synthetase Produkte verfügbar.

Synonyme:: Aat-gly, CG6778, CMT2D, Dmel\\CG6778, DSMAV, fb02f03, gars, GB13467, Gena201, GENA202, GlyRS, GRS, HMN5, MGC79495, Nmf249, RGD1559871, Sgrp23, si:dkey-276i5.1, SMAD1, team, wu:fb02f03

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	GARS	2617	P41250
	GARS	297113
	GARS	353172	Q9CZD3
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Verknüpfte Pathways mit anti-Glycyl-tRNA Synthetase Antikörper

Ribonucleoside Biosynthetic Process

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Human Glycyl-tRNA Synthetase (GARS) Interaktionspartner

In this Chinese Han population a novel Charcot-Marie-Tooth disease-associated gene mutations of GARS (c.794C>T) was discovered.
At the active site, a glycyl-AMP (zeige APRT Antikörper) molecule is synthesized and is waiting for the transfer of the glycyl moiety to occur.
GlyRS functions as a chaperone that critically supports neddylation.
Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.
one of the mRNAs isoforms tightly controls expression and localization of human GARS.
This study reports two crystal structures of human GlyRS variants, in the free form and in complex with tRNA(Gly) respectively, and reveal new aspects of the glycylation mechanism.
GARS mutations are an uncommon cause of Charcot-Marie-Tooth Disease (CMT) in Taiwan. The p.Asp146Tyr and p.Met238Arg mutations are associated with early-onset axonal CMT.
Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.
Expression of three CMT-mutant GARS proteins in Drosophila induces defects in motor performance and motor and sensory neuron morphology, and shortens lifespan.
The c.999G>T mutation is a novel mutation of the glycyl-tRNA synthetase gene that has not been previously reported. The phenotype of this family is Charcot-Marie-Tooth disease type 2D, which is first reported in Chinese population.

Fruit Fly (Drosophila melanogaster) Glycyl-tRNA Synthetase (GARS) Interaktionspartner

Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

Mouse (Murine) Glycyl-tRNA Synthetase (GARS) Interaktionspartner

Results link the aberrant GlyRS-HDAC6 (zeige HDAC6 Antikörper) interaction to Charcot-Marie-Tooth disease type 2D pathology and suggest HDAC6 (zeige HDAC6 Antikörper) as an effective therapeutic target.
findings link the selective pathology of Charcot-Marie-Tooth disease type 2D to the neomorphic binding activity of GlyRS(CMT2D) that antagonizes the VEGF (zeige VEGFA Antikörper)-Nrp1 (zeige NRP1 Antikörper) interaction, meaning the VEGF (zeige VEGFA Antikörper)-Nrp1 (zeige NRP1 Antikörper) signalling axis is an actionable target for treating CMT2D
Results indicate that Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) phenotype is caused by novel pathogenic roles for the mutant GARS that specifically affect peripheral neurons.
a glycyl-tRNA synthetase (GARS) mutation causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy
Gars(C201R) mutation significantly delayed disease onset in the SOD1 (zeige SOD1 Antikörper)(G93A);Gars(C201R/+) double heterozygous mutant mice and increased lifespan by 29% on the genetic background investigated

Zebrafish Glycyl-tRNA Synthetase (GARS) Interaktionspartner

Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

Pig (Porcine) Glycyl-tRNA Synthetase (GARS) Interaktionspartner

Expression levels of ADSL, GARS-AIRS-GART, and DGAT1 were higher in longissimus lumborum muscle than in heart or liver tissues

Glycyl-tRNA Synthetase (GARS) Antigen-Profil

Beschreibung des Gens

This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Alternative names and synonyms associated with Glycyl-tRNA Synthetase (GARS)

glycyl-tRNA synthetase (GARS) Antikörper
Glycyl-tRNA synthetase (GlyRS) Antikörper
glycyl-tRNA synthetase (Gars) Antikörper
glycine--tRNA ligase (LOC408392) Antikörper
glycyl-tRNA synthetase L homeolog (gars.L) Antikörper
glycyl-tRNA synthetase (gars) Antikörper
glycyl-tRNA synthetase (LOC692991) Antikörper
glycine--tRNA ligase (glyQ) Antikörper
glycyl-tRNA synthetase (TTHA0543) Antikörper

Aat-gly Antikörper
CG6778 Antikörper
CMT2D Antikörper
Dmel\\CG6778 Antikörper
DSMAV Antikörper
fb02f03 Antikörper
gars Antikörper
GB13467 Antikörper
Gena201 Antikörper
GENA202 Antikörper
GlyRS Antikörper
GRS Antikörper
HMN5 Antikörper
MGC79495 Antikörper
Nmf249 Antikörper
RGD1559871 Antikörper
Sgrp23 Antikörper
si:dkey-276i5.1 Antikörper
SMAD1 Antikörper
team Antikörper
wu:fb02f03 Antikörper

Bezeichner auf Proteinebene für GARS

AP-4-A synthetase , Charcot-Marie-Tooth neuropathy 2D , Charcot-Marie-Tooth neuropathy, neuronal type, D , diadenosine tetraphosphate synthetase , glycine tRNA ligase , glycine--tRNA ligase , Aats-gly-PA , Aats-gly-PB , Aats-gly-PC , CG6778-PA , CG6778-PB , CG6778-PC , glycyl-tRNA synthetase , glyRS , storage granule protein 23 , glycyl-tran synthetase

GENE ID	SPEZIES
2617	Homo sapiens
39644	Drosophila melanogaster
297113	Rattus norvegicus
353172	Mus musculus
408010	Bos taurus
408392	Apis mellifera
428403	Gallus gallus
446482	Xenopus laevis
463329	Pan troglodytes
475268	Canis lupus familiaris
493218	Xenopus (Silurana) tropicalis
692991	Bombyx mori
884595	Chlamydia trachomatis D/UW-3/CX
3169948	Thermus thermophilus HB8
100174405	Pongo abelii
100388470	Callithrix jacchus
337230	Danio rerio
100512260	Sus scrofa
100723446	Cavia porcellus
101926831	Macaca fascicularis

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