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CTPS2 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin.
Low CTPS2 expression may be a rationally-based determinant of 5FU resistance.
analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
CTP synthase II
, CTP synthetase 2
, UTP--ammonia ligase 2
, CTP synthase 2-like
, cytidine triphosphate synthase II
, CTP synthetase type 2
, UTP-ammonia ligase 2
, cytidine 5'-triphosphate synthetase 2
, cytidine 5'-triphosphate synthase 2
, CTP synthase 2
, CTP synthetase homolog