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The above findings suggest that USP39 plays a vital oncogenic role in the tumorigenesis of prostate cancer
Knockdown of USP39 expression in osteosarcoma cell line U2OS cell significantly decreased cell proliferation, impaired colony formation ability. A further analysis indicated suppression of USP39 arrested cell cycle progression at G2/M phase via p21 (zeige CDKN1A Proteine) dependent way. In addition, the results of Annexin V (zeige ANXA5 Proteine)/7-AAD staining suggested the knockdown of USP39 could promote U2OS cell apoptosis through PARP cleavage.
Data suggest that ZIP (zeige DAPK3 Proteine), USP39, Prp24/p100/SART3, and Prp43 (zeige DHX15 Proteine) associate to form complex instrumental in spliceosome assembly; ZIP (zeige DAPK3 Proteine) regulates pre-mRNA splicing of USP39 independent of RNA binding; stable 35S tri (zeige VANGL2 Proteine)-snRNP (zeige LSM2 Proteine) particles are enriched in Cajal body. (ZIP (zeige DAPK3 Proteine) = zinc finger and G-patch domain-containing protein (zeige ZGPAT Proteine); SART3 (zeige SART3 Proteine) = squamous cell carcinoma antigen recognised by T cells 3 (zeige SART3 Proteine); Prp43 (zeige DHX15 Proteine) = RNA helicase Prp43 (zeige DHX15 Proteine))
High USP39 expression is associated with colon and lung cancer.
Data show that knockdown of ubiquitin specific peptidase 39 (USP39), a direct target of microRNA microRNA-133a, induced cell apoptosis through inhibition of proto-oncogene (zeige RAB1A Proteine) proteins c-akt (AKT (zeige AKT1 Proteine)) signaling pathway in pancreatic cancer (PC) cells.
Results show a significantly higher expression of USP39 in colorectal cancer tissues and cell lines and provide evidence that USP39 protein plays an important role in the growth and metastasis of colorectal cancer mainly through Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.
shRNA-mediated knockdown of USP39 inhibited the growth and colony formation ability of GC cells. suppression of USP39 induced G2/M-phase arrest and increased the cleavage of PARP (Asp214).
USP39 is upregulated in melanoma tissues and that it is implicated in melanoma progression by regulating cell cycle and apoptosis via ERK1/2 signal pathways.
study indicates that USP39 may be functionally involved in lung cancer growth and act as a potential molecular target for human lung cancer diagnosis and treatment.
Our data indicate that USP39 knockdown inhibited the growth of HCC (zeige FAM126A Proteine) both in vitro and in vivo through G2/M arrest, which was partly achieved via the inhibition of FoxM1 (zeige FOXM1 Proteine) splicing.
High expression of ubiquitin-specific peptidase 39 is associated with the development of vascular remodeling.
Zebrafish usp39 (zeige USP37 Proteine) regulates embryonic pituitary homeostasis by targeting rb1 (zeige RB1 Proteine) and e2f4 (zeige E2F4 Proteine) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators
May play a role in mRNA splicing. It is unsure if the protein really exhibits hydrolase activity. Could be a competitor of ubiquitin C-terminal hydrolases (UCHs).
, SnRNP assembly defective 1 homolog
, U4/U6.U5 tri-snRNP-associated 65 kDa protein
, U4/U6.U5 tri-snRNP-associated protein 2
, inactive ubiquitin-specific peptidase 39
, small nuclear ribonucleoprotein 65kDa (U4/U6.U5)
, ubiquitin specific protease 39
, ubiquitin specific peptidase 39
, U4/U6.U5 tri-snRNP-associated protein 2-like
, u4/U6.U5 tri-snRNP-associated protein 2-like