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Specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of human Gemin2.
The authors propose that Gemin2 is a versatile hub for ribonucleoprotein exchange that functions broadly in RNA metabolism.
Two monoclonal antibodies against SMN (zeige STMN1 Proteine) (survival-of-motor-neurons) protein bind to its site of interaction with gemin2.
several conserved SMN (zeige STMN1 Proteine) residues, including the sites of two SMA (zeige SMN1 Proteine) patient mutations, are not required for binding to Gemin2. Instead, they form a conserved SMN (zeige STMN1 Proteine)/Gemin2 surface that may be functionally important for snRNP (zeige LSM2 Proteine) assembly.
Overexpression of SIP1 and downregulation of E-cadherin (zeige CDH1 Proteine) is associated with delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy
purified SMN (zeige STMN1 Proteine)-GEMIN2 fusion protein enhanced the RAD51 (zeige RAD51 Proteine)-mediated homologous pairing much more efficiently than GEMIN2 alone
Study identified Gemin2 as the protein that binds a pentamer of Sm proteins comprised of SmD1 (zeige SNRPD1 Proteine)/D2 and SmF (zeige SNRPF Proteine)/E/G; the crystal structure of this complex bound to SMN's Gemin2 binding domain to 2.5 A was determined.
Novel monoclonal antibodies detect SIP1 in the cytoplasm of human cells from multiple tumor tissue arrays.
This study demonstrated that miR (zeige MLXIP Proteine)-141 levels correlate inversely with SIP1 protein levels as well as cell migration and invasion of CRC (zeige CALR Proteine) cells; SIP1 was identified as a functional target of miR (zeige MLXIP Proteine)-141.
This study supports the rationale for developing SIP1 as a potential therapeutic and diagnostic target for gliomas
utilised a targeted screen to identify mRNA associated with SMN (zeige STMN1 Proteine), Gemin2 and Gemin3 (zeige DDX20 Proteine) in the cytoplasm of a human neuroblastoma (zeige ARHGEF16 Proteine) cell line, SHSY5Y
Gene targeting in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death (gemin2; SMN interacting protein 1)
Reduction of Gemin2, unlike reduction of SMN (zeige SNRPN Proteine), in zebrafish embryos does not directly cause motor axon outgrowth defects.
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
SMN interacting protein 1-delta
, component of gems 2
, gem-associated protein 2
, survival of motor neuron protein interacting protein 1
, SMN-interacting protein 1
, survival of motor neuron protein-interacting protein 1
, survivor of motor neuron protein interacting protein 1
, SMN interacting protein-1
, Survival of motor neuron protein-interacting protein 1