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in human CD4(+) T cells, eIF6 levels rapidly increase upon T-cell receptor activation and drive the glycolytic switch and the acquisition of effector functions
Studies indicate that eukaryotic translation initiation factor 6 (eIF6) is a central regulator of metabolism independent from mTOR protein and myc proto-oncogene protein (Myc).
Propose that eIF6 is necessary for malignant pleural mesothelioma growth.
EIF6 plays an important role in controlling cell motility and tumor metastasis.
eIF6 is a node regulator of ribosomal function and predict that prioritizing its pharmacological targeting will be of benefit in cancer and Shwachman-Bodian-Diamond syndrome
SBDS protein facilitates the release of eIF6, a factor that prevents ribosome joining.
eIF6 is one of the downstream effectors of Notch-1 in the pathway that controls cell motility and invasiveness in tumor cell lines
The interactions between P311 and ITGB4BP may be very important in the process of tumor cell differentiation and metastasis.
The benign prognosis of the Shwachman-Diamond syndrome patients with the int del (20)(q11.21q13.32) may be due to a gene/dosage effect for the EIF6 protein.
Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6) and hnRNA splicing (SF3B2/SF3B4), showed that human T cells can enter the cell cycle without growing in size.
a direct role for SBDS and EFL1 in catalyzing the translational activation of ribosomes in all eukaryotes, and define SDS as a ribosomopathy caused by uncoupling GTP hydrolysis from eIF6 release
P311 and ITGB4BP expression was elevated in non-small cell lung cancer, possibly indicative of a new signaling pathway.
Ca(2+)-activated calcineurin phosphatase binds to and promotes nuclear localization of eIF6.Nuclear export of eIF6 is regulated by phosphorylation at Ser-174 and Ser-175 by the nuclear isoform of CK1.
eIF6 release regulates ribosome subunit joining and RACK1 provides a physical and functional link between PKC signalling and ribosome activation
ITGB4BP is overexpressed in head and neck cancers and its metastases.
Human eIF6 promoter contains consensus sites for the GABP (GA-binding protein) transcription factor complex.
results uncover an evolutionarily conserved function of the ribosome anti-association factor eIF6 in miRNA-mediated post-transcriptional silencing
Nuclear matrix proteins such as mutant Pyst1 and nucleophosmin 1 were downregulated, whereas eIF6 and beta-tubulin were upregulated during cell differentiation in hepatocarcinoma cells.
definitive evidence that eIF6 and dicer are both upregulated in a significant proportion of ovarian serous carcinomas
eIF6 heterozygous mice show an increased mortality during viral infection and a reduction of peripheral blood CD4(+) effector memory T cells
Taken together, these results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-beta1/TGFBR1/TGFBR2 pathway.
eIF6 relieved fibrosis/cicatrization by inhibiting the generation of VEGF to prevent the overgrowth of blood vessels and production of granulation tissues, and by regulating the MMP-2/TIMP-2 balance to promote ECM degradation and decrease its deposition.
data reveal a novel transcriptional regulatory mechanism of eIF6 that acts on facilitating Sp1 recruitment to TGF-beta1 promoter via H2A.Z depletion and thus results in increased TGF-beta1 transcription, which contributes to myofibroblast differentiation.
Reduced eIF6 expression negatively impacts on megakaryopoiesis. in eIF6(+/-) cells, the steady-state abundance of mitochondrial respiratory chain complex I-encoding mRNAs is decreased, resulting in decreased reactive oxygen species production.
eIF6 controls fatty acid synthesis and glycolysis in a cell autonomous fashion. Translational activation by eIF6 reshapes gene expression with increased levels of lipogenic and glycolytic enzymes.
In a murine model of lymphomagenesis, eIF6 depletion leads to a striking increase of survival, without adverse effects.
eIF6 is a rate-limiting controller of initiation of translation, able to affect tumorigenesis and tumor growth.
role in forming nuclear matrix filaments
eIF6 is the first eIF associated with the large 60S subunit that regulates translation in response to extracellular signals
Results suggest that eif6 regulation of Kermit 2/XGIPC (gipc2) enables correct morphogenesis of eye.
aberrant eye phenotype, produced by eif6 overexpression, is not directly linked to the PKC-regulated effects of eif6 on translation and ribosomal subunit interaction
The higher presence of p27BBP/eIF6 would appear related to an increased need of apoptosis control in the regions where cell death is essential for normal development.
Xp27(BBP)/eIF6 is part of a mechanism acting on the specific translation of messengers regulating cell survival; Xp27(BBP)/eIF6 may regulate the translation of factors upstream of Bcl-2/Bax.
The distribution of p27BBP/eIF6 and its association with the cytoskeleton varies according to oogenesis stages.
p27BBP/eIF6 expression is modulated during embryogenesis in differentiating anlagens and may suggest a correlation between p27BBP/eIF6 and proliferative activity.
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.
B4 integrin interactor
, eukaryotic translation initiation factor 3A
, p27 beta-4 integrin-binding protein
, integrin beta 4 binding protein
, imc-415 homolog
, eukaryotic translation initiation factor 6