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Results show pervasive yet nonuniform contributions of the decapping enzyme (zeige DCP1A ELISA Kits) Dcp2 (zeige DCP2 ELISA Kits) and the deadenylase Cnot7 to maternal mRNA clearance.
Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover
MEX3C (zeige MEX3C ELISA Kits) associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7.
CNOT7/hCAF1 (zeige CNOT8 ELISA Kits) is involved in ICAM-1 (zeige ICAM1 ELISA Kits) and IL-8 (zeige IL8 ELISA Kits) regulation by TTP (zeige ADAMTS13 ELISA Kits) in HPMEC.
CNOT7 is an antimicrobial protein and a regulator of the innate immune response.
The anti-proliferative activity of BTG/TOB (zeige TDO2 ELISA Kits) proteins is mediated via the Caf1a (zeige CHAF1B ELISA Kits) (CNOT7) and Caf1b (zeige CHAF1A ELISA Kits) (CNOT8 (zeige CNOT8 ELISA Kits)) deadenylase subunits of the Ccr4 (zeige CCR4 ELISA Kits)-not complex.
CNOT7 is not the target tumor suppressor gene in the 8p22-23.1 colorectal cancer suppressor (zeige DCC ELISA Kits) region.
CAF1 (zeige CHAF1B ELISA Kits) is a new regulator of PRMT1 (zeige PRMT1 ELISA Kits)-dependent arginine methylation.
antiproliferative region of human Tob (zeige TDO2 ELISA Kits) (residues 1-138) and intact hCaf1 (zeige CNOT8 ELISA Kits) were co-expressed in Escherichia coli, purified and successfully cocrystallized
Data show that Ccr4 (zeige CCR4 ELISA Kits)-Not function in RNA splicing and nuclear export, and that CNOT7 binds strongly with CNOT6 (zeige CNOT6 ELISA Kits).
Data show that efficient cell proliferation requires both CNOT7 and CNOT8 (zeige CNOT8 ELISA Kits), although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins.
study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
Cnot7, a key component of deadenylation machinery, are also dormant maternal mRNAs that are recruited during oocyte maturation
Collectively, our data support a model of CNOT7, TOB1, CNOT1 (zeige CNOT1 ELISA Kits), and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis
MK2 (zeige KCNA2 ELISA Kits) phosphorylation reduces the ability of TTP (zeige ZFP36 ELISA Kits) to promote deadenylation by inhibiting the recruitment of CAF1 deadenylase in a mechanism that does not involve sequestration of TTP (zeige ZFP36 ELISA Kits) by 14-3-3 (zeige YWHAQ ELISA Kits).
mCAF1 (zeige ATF7IP ELISA Kits)-deficient mouse phenotype could be linked to a defect(s) in germ cells and/or to inadequate Sertoli cell function, leading to seminiferous tubule disorganization and finally to a total disappearance of germ cells
Gene deletion of Cnot7 caused abnormal sperm morphology in Sertoli cells from knockout mice.
Cnot7 is expressed in osteoblasts and is associated with mineralization.
Cnot7 is an endogenous suppressor of bone mass in adult mice and inhibits bone mass phenotype actions
Show that a let-7 miRNA-loaded RNA-induced silencing complex interacts with the poly(A)-binding protein and the CAF1 and CCR4 (zeige CCR4 ELISA Kits) deadenylases for miRNA mediated deadenylation.
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
CCR4-NOT transcription complex, subunit 7
, CCR4-NOT transcription complex subunit 7
, ccr4-not transcription complex, subunit 7
, CCR4-associated factor 1
, BTG1 binding factor 1
, BTG1-binding factor 1
, carbon catabolite repressor protein (CCR4)-associative factor 1
, POP2 homolog
, catabolite repressor protein (CCR4)-associative factor 1