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results highlight the clinical significance of PARN (zeige PARN Antikörper) and NOC on the survival in SCC (zeige CYP11A1 Antikörper) diagnosed patients.
Three tag SNPs (rs938836, rs17050680, rs3805213) in the CCRN4L are significant correlation with genotype and allele frequency in lung cancer.
Genetic variation in the NOC gene is associated with body mass index in Chinese subjects.
Ccr4d functions as an anti-proliferating protein through the induction of cell cycle arrest via a p21 (zeige CDKN1A Antikörper)-dependent and p53 (zeige TP53 Antikörper)-independent pathway and suggest that Ccr4d might have an important role in carcinogenesis.
A human lung cancer cell line SBC-5 that efficiently metastasized to bone when intravenously injected into SCID (zeige PRKDC Antikörper) mice was found to express CCR4 (zeige CCR4 Antikörper).
The transcription of human nocturnin gene displayed circadian oscillations in Huh7 cells (a human hepatoma cell line) and was regulated by CLOCK/BMAL1 heterodimer via the E-box of nocturnin promoter.
Data suggest that Nocturnin (NOC) exerts strong effects on physiology through direct and indirect control of target mRNAs.
precise expression of nocturnin is critical to proper development of early mouse embryos
Nocturnin plays a role in linking nutrient sensing by the circadian clock to lipid mobilization in the adipocytes
data suggest that Nocturnin has a novel stabilizing activity that plays an important role in the circadian response to inflammatory signals
Loss of nocturnin enhances bone formation; the circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate.
Data suggest that nocturnin plays an important role in the trafficking of dietary lipid in the intestinal enterocytes by optimizing efficient absorption of lipids.
Noc interacts with Igf1 (zeige IGF1 Antikörper) in a strain- and tissue-specific manner and reduces Igf1 (zeige IGF1 Antikörper) expression by targeting the longer form of the Igf1 (zeige IGF1 Antikörper) 3'UTR (zeige UTS2R Antikörper).
Noc plays a unique role in the regulation of mesenchymal stem-cell lineage allocation by modulating PPAR-gamma (zeige PPARG Antikörper) activity through nuclear translocation.
Nocturnin, is markedly upregulated with Pparg (zeige PPARG Antikörper) activation in adipocytes and bone marrow stromal cells.
nocturnin exhibits circadian rhythmicity of mRNA abundance with peak levels at the time of light offset in the retina, spleen, heart, kidney and liver.
We found that the amino acid sequences of zebrafish nocturnin-a and nocturnin-b are highly similar to those of frog, mouse, and human nocturnin homologs. Only nocturnin-b is expressed in the eye. Within the retina, nocturnin-b mRNA was expressed at higher levels in the retinal photoreceptors layer than in other cellular layers. This expression pattern echoes the restricted photoreceptor expression of nocturnin in the fro
Data suggest that nocturnin deadenylates clock-related transcripts in a novel mechanism for posttranscriptional regulation in the circadian clock or its outputs.
nocturnin is a circadian clock-regulated gene identified by differential display
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.
CCR4 protein homolog
, CCR4-like (carbon catabolite repression 4, S.cerevisiae)
, CCR4 carbon catabolite repression 4-like
, carbon catabolite repression 4 homolog
, CCR4 carbon catabolite repression 4-like B
, carbon catabolite epression 4 homolog
, CCR4 carbon catabolite repression 4-like, nocturnin
, rhythmic message 1