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anti-Human EZH2 Antikörper:
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Human Polyclonal EZH2 Primary Antibody für ChIPSeq, ChIP - ABIN2668958
Knutson, Kawano, Minoshima, Warholic, Huang, Xiao, Kadowaki, Uesugi, Kuznetsov, Kumar, Wigle, Klaus, Allain, Raimondi, Waters, Smith, Porter-Scott, Chesworth, Moyer, Copeland, Richon, Uenaka, Pollock et al.: Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. ... in Molecular cancer therapeutics 2014
Show all 9 Pubmed References
Human Monoclonal EZH2 Primary Antibody für ChIP - ABIN2668955
Bengani, Mendiratta, Maini, Vasanthi, Sultana, Ghasemi, Ahluwalia, Ramachandran, Mishra, Brahmachari: Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome. in PLoS ONE 2013
Show all 8 Pubmed References
Human Polyclonal EZH2 Primary Antibody für WB - ABIN2668957
Izzo, Mercogliano, Venturutti, Tkach, Inurrigarro, Schillaci, Cerchietti, Elizalde, Proietti: Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth. in Breast cancer research : BCR 2015
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Chicken Monoclonal EZH2 Primary Antibody für IF, WB - ABIN968906
Raaphorst, Otte, van Kemenade, Blokzijl, Fieret, Hamer, Satijn, Meijer: Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation. in Journal of immunology (Baltimore, Md. : 1950) 2001
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Chicken Monoclonal EZH2 Primary Antibody für IF, WB - ABIN968907
van Kemenade, Raaphorst, Blokzijl, Fieret, Hamer, Satijn, Otte, Meijer: Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. in Blood 2001
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Polyclonal EZH2 Primary Antibody für WB - ABIN540724
Hobert, Jallal, Ullrich: Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. in Molecular and cellular biology 1996
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Human Polyclonal EZH2 Primary Antibody für WB - ABIN2668964
Kaneko, Li, Son, Xu, Margueron, Neubert, Reinberg: Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. in Genes & development 2010
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Human Polyclonal EZH2 Primary Antibody für ICC, IF - ABIN438771
Hyland, McDade, McCloskey, Dickson, Arthur, McCance, Patel: Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes. in Journal of virology 2011
Human Monoclonal EZH2 Primary Antibody für IF, IHC (p) - ABIN659002
Tsai, Manor, Wan, Mosammaparast, Wang, Lan, Shi, Segal, Chang: Long noncoding RNA as modular scaffold of histone modification complexes. in Science (New York, N.Y.) 2010
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Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
EZH2 and HOTAIR promote the progression of the urinary bladder cancer.
EZH2 may have a role in invasive cervical carcinoma
Meta-analysis: EZH2 expression is significantly correlated with aggressive tumor behavior and poor prognosis in non-small cell lung cancer.
Kaplan-Meier survival analysis indicated that EZH2 overexpression is associated with endometrial cancer prognosis. In addition, knockdown of EZH2 using specific siRNAs resulted in growth suppression and apoptosis induction of endometrial cancer cells, accompanied by attenuation of H3K27 trimethylation.
The antitumor efficacy of pharmacological EZH2 inhibition depends on SESTRIN1, indicating that mTORC1 control is a critical function of EZH2 in lymphoma.
LncRNA-ANCR (zeige ube3a Antikörper) inhibited the cell proliferation, migration, and invasion of osteosarcoma cells, possibly through interacting with EZH2 and regulating the expression of p21 (zeige CDKN1A Antikörper) and p27 (zeige PAK2 Antikörper).
sodium valproate (NaVP)has a function in blocking the growth, invasion, and angiogenesis of tumor in the chorioallantoic membrane model; tumor growth interferes with EZH2 and p53 (zeige TP53 Antikörper) molecular pathways, supporting the NaVP potential in GBM therapy.
Study shows that linc00673 could directly bind with EZH2 which represses HOXA5 (zeige HOXA5 Antikörper) expression.
Studies indicate that enhancer of zeste homolog 2 (EZH2) is a potential target for cancer therapy and a variety of inhibitors have been developed [review].
Confirmation of an oncogenic role for LINC00319 in clinical specimens and cellular experiments, showing the potential LINC00319/miR (zeige MLXIP Antikörper)-450b-5p/EZH2 pathway in lung adenocarcinoma tumorigenesis.
cardiomyocyte-specific loss of Ezh2 did not affect fibrotic scar size after MI or apical resection at P7, suggesting that it does not extend the regenerative time window. Our results demonstrate that Ezh2 is not required for innate neonatal cardiac regeneration
results, together with our previous report, support a cell lineage-specific mechanism of Ezh2-mediated gene repression, especially those critically involved in cellular function and homeostasis
CARM1 (zeige CARM1 Antikörper) promotes EZH2-mediated silencing of EZH2/BAF155 (zeige SMARCC1 Antikörper) target tumor suppressor genes by methylating BAF155 (zeige SMARCC1 Antikörper).
EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A (zeige CDKN1A Antikörper) and release of cell cycle checkpoints.
Suggest that EZH1 (zeige EZH1 Antikörper) and -2 are novel targets of miR (zeige MLXIP Antikörper)-214-3p, and miR (zeige MLXIP Antikörper)-214-3p might be one potential miRNA for the prevention of cardiac fibrosis.
It has been demonstrated that FAK (zeige PTK2 Antikörper) depletion reduces hepatocellular carcinoma cell growth by affecting cancer-promoting genes including the pro-oncogene (zeige RAB1A Antikörper) EZH2.
ompounding a previously described Bmi1 (zeige BMI1 Antikörper)-transgene and Pten-deficiency prostate cancer mouse model with the Ezh2 transgene did not enhance tumour progression or drive metastasis formation. In conclusion, we here report the generation of a wildtype Ezh2 overexpression mouse model that allows for intravital surveillance of tissues with activated transgene
decline in HDAC9c expression over time was accompanied by increased EZH2 expression.
Long non-coding RNA LOC554202 may play an important role in the progression of chordoma by the direct upregulation of EZH2 and indirect promotion of RNF144B (zeige RNF144B Antikörper) via miR (zeige MLXIP Antikörper)-31
Gfi1 (zeige ZNF163 Antikörper) disruption antagonized the tumor-promoting effects of Ezh2 loss; conversely, Gfi1 (zeige ZNF163 Antikörper) overexpression collaborated with Myc (zeige MYC Antikörper) to bypass effects of Trp53 (zeige TP53 Antikörper) inactivation in driving medulloblastoma progression in primary cerebellar neuronal progenitors.
Ezh2 is essential to sustain tissue integrity and to set up proper maternal mRNA contribution.
ezh2-deficient mutants fail to properly regenerate their spinal cord after caudal (zeige CAD Antikörper) fin transection suggesting that Ezh2 and H3K27me3 methylation might also be involved in the process of regeneration in zebrafish.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2