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Human CTBP1 Protein expressed in HEK-293 Cells - ABIN2712600
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
In zebrafish hair cells exogenous Ribeye (zeige CTBP2 Proteine) B-domain and CtBP1 localize to the basal ends of synaptic ribbons.
Tel (zeige ETV6 Proteine) orchestrates endothelial sprouting by binding to the generic co-repressor, CtBP (zeige CTBP2 Proteine)
Study reports a recurrent de novo C-terminal binding protein 1 (CTBP1) mutation is associated with developmental delay, hypotonia, ataxia, and tooth enamel defects. This is the first report of mutations within CTBP1 in association with any human disease.
Pinin (zeige PNN Proteine) and CtBP1 and CtBP2 (zeige CTBP2 Proteine) are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells.
the importance of the oligomeric state of CtBP for coactivation of NeuroD1-dependent transcription, was investigated.
C-terminal binding protein 1 is a critical factor linking changes in cell metabolism to cell phenotype in hypoxic and other forms of pulmonary hypertension
CtBP1 increased breast tumor growth in MeS (zeige ME1 Proteine) mice modulating multiple genes and miRNA expression implicated in cell proliferation, progenitor cells phenotype, epithelial to mesenchymal transition, mammary development and cell communication in the xenografts.
These data uncovered that CtBP1 protein is a valuable marker of glioma pathogenic process and that CtBP1 can serve as a novel prognostic marker for glioma therapy.
human chorionic gonadotropin stimulated miR (zeige MLXIP Proteine)-212, which down-regulated OLFM1 (zeige OLFM1 Proteine) and CTBP1 expression in fallopian and endometrial epithelial cells to favor spheroid attachment
It is a putative target gene of miR (zeige MLXIP Proteine)-137 in breast neoplasms.
CtBP physically interacted with TCF-4, and this interaction was significantly inhibited in the presence of MTOB. The above findings point to a novel role of CtBPs in the promotion of CSC growth and self-renewal
High CtBP1 expression is associated with Prostate tumor.
Study determined that PCBP2 (zeige PCBP2 Proteine) specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.
data suggest that PCBP2 (zeige PCBP2 Proteine) regulates p73 (zeige ARHGAP24 Proteine) expression via mRNA stability and p73 (zeige ARHGAP24 Proteine)-dependent biological function in ROS (zeige ROS1 Proteine) production and cellular senescence.
PCBP2 (zeige PCBP2 Proteine) overexpression rescues the Meis1 (zeige MEIS1 Proteine) effects of Akt (zeige AKT1 Proteine)-mTOR (zeige FRAP1 Proteine) pathway and hypertrophy of cardiomyocytes.
These data reveal that Pcbp1 (zeige PCBP1 Proteine) and Pcbp2 (zeige PCBP2 Proteine) are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
PCBP2 (zeige PCBP2 Proteine) knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 (zeige PCBP2 Proteine) overexpression obtained oppose effects.
Our analysis of PCBP1 (zeige PCBP1 Proteine) and PCBP2 (zeige PCBP2 Proteine) expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.
This study demonstrates for the first time that alpha-CP2 (zeige PCBP2 Proteine) functions as a transcriptional activator by binding to a single-stranded poly(C) sequence.
This study provides evidence that PCBP2 (zeige PCBP2 Proteine) and hnRNP A1 (zeige HNRNPA1 Proteine) bind to the 5' and 3' ends of the murine norovirus 1 viral RNA and contribute to RNA circularization, playing a role in the virus life cycle.
CtBP1 protein is not essential for the formation of functional ribbon synapses in the retina.
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
C-terminal binding protein 1
, C-terminal-binding protein 1
, C-terminal-binding protein 1-like
, c-terminal-binding protein 1-like
, brefeldin A-ribosylated substrate
, C-terminal-binding protein A
, 50 kDa BFA-dependent ADP-ribosylation substrate
, 50-kDa BFA-induced ADP-ribosylated substrate
, C-terminal-binding protein 3
, C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate
, brefeldin A-ADP-riboslyated substrate
, heterogeneous nuclear ribonucleoprotein X
, hnRNP X
, poly(rC)-binding protein 2
, putative heterogeneous nuclear ribonucleoprotein X