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Data show that hRALDH2 is not inhibited by its oxidation product, all-trans-RA, suggesting the absence of a negative feedback regulatory loop. Expression of the Raldh2 gene is known to be regulated by RA itself, suggesting that the main regulation of the hRALDH2 activity level is transcriptional.
Study shows no evidence that genetic variants alter prostate cancer incidence, but show that SNPs in the ALDH1A2 gene affect prostate cancer mortality.
a critical role of ALDH1A2-RAR (zeige RARA Proteine) signaling in the pathogenesis of head and neck cancer.
High expression of ALDH1A2 and ALDH1B1 (zeige ALDH1B1 Proteine) mRNA was found to be significantly correlated to worser survival in all NSCLC patients.
the distribution of RALDH1 (zeige ALDH1A1 Proteine), RALDH2, and RALDH3 (zeige ALDH1A3 Proteine) in the postnatal eye was determined.
ALDH1A2 is involved in the regulation of cancer stem cell properties in neuroblastoma (zeige ARHGEF16 Proteine).
Genetic association replicative and exploratory studies identify SNPs in ADA (zeige ADA Proteine) and MTR (zeige MTR Proteine) highly associated with isolated Neural tube defects (NTD)and SNP in ARID1A and ALDH1A2 associated with NTDs in whites and African Americans respectively.
At the transcript level, the cisplatin + DEAB-resistant cells showed upregulated mRNA expression levels for ALDH1A2, ALDH1A3 (zeige ALDH1A3 Proteine) isozymes and CD44 (zeige CD44 Proteine) indicating the involvement of these markers in conferring chemoresistance
DNA methylation (zeige HELLS Proteine) at multiple CpG sites is associated with loss of control over alcohol drinking.
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.
Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of Raldh2 directly.
The novel aldh1a2 reporter line is driven by the complete set of regulatory sequences required for zebrafish development, reports novel sources of RA synthesis, and identifies the source of RA that promotes vertebral ossification.
aldh1a2 participate to a positive loop required for branchial arches development in zebrafish
Aldh1a2 is the primary aldehyde dehydrogenase acting during pancreas development and maternal Aldh1a2 activity persists in aldh1a2(um22) and aldh1a2(i26) mutant embryos.
Studies indicate that raldh2 expression is critical for the formation of wound epithelium and blastema.
data do not support the hypothesis that retinal itself represses weight gain and adipogenesis independently of RA. Instead, the data indicate that Raldh1 (zeige ALDH1A1 Proteine) functions as a retinal and atRA-independent promoter of adiposity during adolescence, and enhances adiposity through pre-adipocyte cell autonomous actions
these studies identify Notch (zeige NOTCH1 Proteine) signaling in dendritic cells as a crucial balancer of Th17/iTreg, which depends on the direct regulation of Aldh1a2 (zeige ALDH1A1 Proteine) transcription in dendritic cells
ALDH2 (zeige ALDH2 Proteine) mutation displays an inverse correlation of coronary collateral vessel formation in patients.
Data suggest that retinoic acid and GM-CSF (zeige CSF2 Proteine)-induced retinal dehydrogenase 2 (RALDH2) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (zeige SP1 Proteine) via the RA receptor/retinoid X receptor (zeige RXRB Proteine) complex to the Aldh1a2 (zeige ALDH1A1 Proteine) promoter.
all three proteins (RDH10 (zeige RDH10 Proteine), RALDH2, and CRABP2 (zeige CRABP2 Proteine)) appeared to be required for ATRA production induced by activation of PPARgamma (zeige PPARG Proteine)
Defects in interdigital programmed cell death and digit separation in Hoxa13 (zeige HOXA13 Proteine) mutant mice may be caused in part by reduced levels of RA signaling stemming from a loss in the direct regulation of Aldh1a2 (zeige ALDH1A1 Proteine)
Raldh1 (zeige ALDH1A1 Proteine) and Raldh3 (zeige ALDH1A3 Proteine) influence enteric nervous system structure and function and heterozygosity for Raldh2 causes ENS defects
ALDH1A2 expression was highest in ALDH(very-br) cells, intermediate in ALDH(dim) cells, and lowest in ALDH(br) cells.
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
rendered Fgfr2IIIb (zeige FGFR2 Proteine)(-/-) embryos haploinsufficient for the Raldh2 and examined these embryos for the incidence and severity of duodenal atresia
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.
, aldehyde dehydrogenase 1A2
, aldehyde dehydrogenase family 1 member A2
, aldehyde dehydrogenase family 1, subfamily A2
, retinal dehydrogenase 2
, retinal dehydrogenase, type II
, retinaldehyde-specific dehydrogenase type 2
, retinaldehyde dehydrogenase 2
, alcohol dehydrogenase family 1, subfamily A2
, alcohol dehydrogenase family 1, subfamily A7