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Overexpression of AKR1C3 could result in the accumulation of prostaglandin F2alpha (PGF2alpha), which can not only promote prostate cancer cell 's proliferation but also could enhance prostate cancer cells resistance to radiation.
The replacement of C154 with a residue possessing a bulky aromatic side-chain impairs the folding of the alpha-helix containing C154 and its neighboring secondary structures, leading to low thermostability of AKR1C3.
Data suggest that, in breast cancer cells, expression of HSD17B5 and expression of GRP78 (zeige HSPA5 Proteine) (an apoptosis inhibitor) are strongly but negatively correlated; GRP78 (zeige HSPA5 Proteine) knockdown decreases breast cancer cell viability whereas HSD17B5 knockdown increases cell viability and cell proliferation. (HSD17B5, 17-beta-hydroxysteroid dehydrogenase 5; GRP78 (zeige HSPA5 Proteine), 78 kDa glucose-regulated protein (zeige HSPA5 Proteine))
AKR1C3 is the primary enzyme and CBR1 (zeige CBR1 Proteine) is a minor enzyme responsible for warfarin reduction in human liver cytosol.
the present study suggests that AKR1C1 (zeige DDH Proteine), AKR1C2 (zeige AKR1C2 Proteine), AKR1C3, and AKR1C4 (zeige AKR1C4 Proteine) are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
a variant in the promoter region of HSD17B5 related to fetal androgen synthesis influences the genital phenotype in 21-Hydroxylase Deficiency females.
Five common AKR1C3 polymorphisms were associated with decreased rates of exemestane catalysis.
If our these findings can be reproduced in larger homogeneous cohorts, a genetic stratification based on the AKR1C3 rs12529 single nucleotide polymorphism, can minimize androgen deprivation therapy-related health-related quality of life effects in prostate cancer patients
We identified strong associations between the studied AKR1C3 variants and UBC (zeige RPS27A Proteine) risk. The homozygous variant genotype of rs12529 was found to be inversely associated with UBC (zeige RPS27A Proteine), and rs1937920 was shown to be associated with increased risk of UBC (zeige RPS27A Proteine). None of the genotypes were found to be significantly associated with tumor characteristics.
aldo-keto reductase 1C3-mediated prostaglandin D2 metabolism has a role in keloids
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
, prostaglandin F synthase
, aldo-keto reductase family 1 member C3 homolog
, 3-alpha hydroxysteroid dehydrogenase, type II
, 3-alpha-HSD type II, brain
, aldo-keto reductase family 1 member C3
, chlordecone reductase homolog HAKRb
, dihydrodiol dehydrogenase 3
, dihydrodiol dehydrogenase X
, indanol dehydrogenase
, testosterone 17-beta-dehydrogenase 5
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, type IIb 3-alpha hydroxysteroid dehydrogenase
, 20 alpha-hydroxysteroid dehydrogenase
, 20-alpha-hydroxysteroid dehydrogenase
, 20alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase family 1 member C18
, aldo-keto reductase family 1, member C18
, 17-beta-HSD 5
, 17-beta-hydroxysteroid dehydrogenase type 5
, 3-alpha-HSD type 2
, 3-alpha-hydroxysteroid dehydrogenase type 2