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Human TPT1 Protein expressed in Wheat germ - ABIN1323472
Sirois, Raymond, Brassard, Cailhier, Fedjaev, Hamelin, Londono, Bendayan, Pshezhetsky, Hébert: Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication. in Cell death and differentiation 2011
The biological effects of Na,K-ATPase (zeige ATP1A1 Proteine) and TCTP interaction are reviewed.
The cells knocked down for TCTP show diminished invasiveness and migration under TGF-beta1 (zeige TGFB1 Proteine) treatment. TGF-beta1 (zeige TGFB1 Proteine) dependent TCTP expression is required for epithelial to mesenchymal transition in cells.
that TPT1 knockdown altered the BECN1 (zeige BECN1 Proteine) interactome, a representative MTOR (zeige FRAP1 Proteine)-independent pathway, to stimulate autophagosome formation
Transfection with TCTP-Lipid modified antisense oligonucleotides led to rapid and prolonged internalization via macropinocytosis, TCTP downregulation and significant decreased cell viability in in castration-resistant prostate cancer cells.
extracellular TCTP has a role as a promoter of colorectal cancer progression and liver metastases via Cdc42 (zeige CDC42 Proteine)/JNK (zeige MAPK8 Proteine)/MMP9 (zeige MMP9 Proteine) activation
The structure of human HRF (hHRF) was solved in 2 new crystal forms, one at the highest resolution (1.4A) yet reported. The high resolution hHRF structure reveals a disulphide-linked dimer, in which the 2 molecules are closely associated and provides a model for the role of HRF in mast cell activation.
analyzed the interactome of TCTP in HeLa cells by coimmunoprecipitation (IP) and mass spectrometry (MS). Results not only reveal a large number of TCTP-associated proteins that possess pleiotropic functions, but also provide novel insights into the molecular mechanisms of TCTP in tumorigenesis
Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.
These findings provide novel data on the role and regulation of TCTP in skeletal muscle in vivo.
TCTP may thus contribute to the development of anti-cancer drug resistance.
The first crystal structure of murine HRF to 4.0A resolution, reveals a conserved fold. A model for the role of murine HRF in mast cell activation was created based on the human HRF structure.
TCTP-mediated spindle dynamics play a key role in maintaining oocyte quality during postovulatory aging. Overexpression of TCTP is sufficient to prevent aging-associated abnormalities in mouse oocytes.
Leads to the enhanced and previously un-described interaction of RACK1 (zeige GNB2L1 Proteine) and TCTP.
These data suggest the presence of a novel oxidative-stress-handling pathway where the anti-p53 (zeige TP53 Proteine) molecule fortilin augments the peroxidase PRX1 (zeige PRDX1 Proteine) by protecting it against degradation and inactivation of the enzyme.
results demonstrate that TCTP is a microtubule-associating protein required to regulate spindle microtubule dynamics during meiotic maturation in mouse oocytes.
TCTP over-expression-induced RhoA (zeige RHOA Proteine) activation indicates that silencing of cellular TCTP may offer therapeutic approaches for the regulation of hypertension by inhibiting RhoA (zeige RHOA Proteine)/Rho kinase (zeige ROCK2 Proteine) pathway and modulating vascular contractility.
osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21
pretreatment of donor cells with phosphorylated TCTP peptide has a beneficial effect on the potential of bovine somatic cell nuclei to develop into normal cloned calves.
A 'Y' transition single feature polymorphism in TCTP between Meishan and white composite swine breeds was identified by expression profiling using the in silico procedure Click-'N-SNP.
This work describes the cloning and structural analysis of a Tpt1 cDNA coding for the porcine translationally controlled tumor protein (TCTP) molecule and its expression in porcine cells and tissues.
Tctp supports the development of the retinotectal projection via its regulation of pro-survival signalling and axonal mitochondrial homeostasis, and establish a novel and fundamental role for Tctp in vertebrate neural circuitry assembly.
Tpt1 activates transcription of oct4 and nanog in transplanted somatic nuclei.
TCTP has molecular properties similar to animal TCTPs, such as tubulin (zeige TUBB Proteine)- and calcium-binding, and that it functions in ABA-mediated stomatal movement, in addition to regulating the growth of plants.
data support a role of plant AtTCTP as a positive regulator of mitotic growth by specifically controlling the duration of the cell cycle.
The results identify TCTP as an important regulator of growth in plants and imply a function of plant TCTP as a mediator of TOR activity similar to that known in nonplant systems.
TCTP may promote the progression of epithelial ovarian cancer and reduce the sensitiveness of HO8910 cells to cisplatin.
TCTP has a role in regulating ATM (zeige ATM Proteine) activity to control genome stability and organ development in Drosophila melanogaster
plant AtTCTP can fully rescue cell proliferation defects in Drosophila loss of function for dTCTP
Our studies identify TCTP as a direct regulator of Rheb (zeige RHEB Proteine) and a potential therapeutic target for tuberous sclerosis disease.
Drosophila TCTP (dTCTP) displays GEF (zeige SLC2A4RG Proteine) activity to Rheb (zeige RHEB Proteine) and is essential for Rheb (zeige RHEB Proteine) activation in organ growth
BmTCTP as a dual-functional protein involved in both the cellular and the humoral immune response of the silkworm
Involved in calcium binding and microtubule stabilization (By similarity).
, histamine-releasing factor
, translationally-controlled tumor protein
, 21 kDa polypeptide under translational control
, translationally regulated transcript (21 kDa)
, lens epithelial protein
, translationally controlled tumor protein
, translationally-controlled tumor protein homolog
, growth-related translationally controlled tumor protein
, growth-related translationally-controlled tumor protein
, tumor protein, translationally-controlled 1
, translationally controlled tumor protein (TCTP)
, translationally controlled tumor protein 3
, translationally controlled tumor protein 4
, P23 tumor protein-like protein
, P23-like protein