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molecular substrate of a chloride channel (zeige CLCA1 ELISA Kits) previously detected in the mouse thick ascending limb
the major component of Cl(-) transport sensitive to NPPB (zeige BNP ELISA Kits) or pH is mediated by CLC-K1 in the tAL (zeige TALDO1 ELISA Kits).
Gene expression profiling in the collecting tubules of aquaporin-1 (zeige AQP1 ELISA Kits) and CLC (zeige CLC ELISA Kits)-Nk1 (zeige HGF ELISA Kits) knockout mice.
induction of SGK1 (zeige SGK1 ELISA Kits), CLC-K1 and barttin (zeige BSND ELISA Kits) by high osmolarity and change in intracellular volume in distal renal tubular cells in vivo and in vitro
Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk.
R8W and G47R, two naturally occurring barttin (zeige BSND ELISA Kits) mutations identified in patients with Bartter syndrome type IV, reduce barttin (zeige BSND ELISA Kits) palmitoylation and CLC-K (zeige CLCNKB ELISA Kits)/barttin (zeige BSND ELISA Kits) channel activity.
HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka (zeige CLCNKB ELISA Kits)/barttin (zeige BSND ELISA Kits) and CLC-Kb (zeige CLCNKB ELISA Kits)/barttin (zeige BSND ELISA Kits) channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved
following variables were significantly associated with an estimated glomerular filtration rate: age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype
The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 (zeige HSPB7 ELISA Kits) gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis.
Identify a protein region that is involved in calcium binding and that is likely undergoing conformational changes underlying the complex gating of CLC-K (zeige CLCNKB ELISA Kits) channels.
Combined impairment of ClC-Ka (zeige CLCNKB ELISA Kits) and ClC-Kb (zeige CLCNKB ELISA Kits) results in phenotype that mimics neonatal Barrter's syndrome with deafness
Barttin (zeige BSND ELISA Kits) modulates trafficking and function of ClC-K1 and ClC-Kb (zeige CLCNKB ELISA Kits) channels
CLCNKA genetic variants may have roles in salt-sensitive hypertension
The structure of the cytoplasmic domain of CLCNKA reveals a conserved interaction interface.
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
chloride channel Ka
, chloride channel protein ClC-Ka-like
, chloride channel K1
, chloride channel protein ClC-Ka
, putative basolateral cTAL chloride channel ClC-Ka
, chloride channel, kidney, A
, Chloride channel protein ClC-Kb
, chloride channel Kb