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anti-HMGCS2 (HMGCS2) Antikörper

Bezeichnung:: anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) Antikörper (HMGCS2)

Auf www.antikoerper-online.de finden Sie aktuell 46 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Antikörper von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HMGCS2 Kits (20) und HMGCS2 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 84 HMGCS2 Produkte verfügbar.

Synonyme:: 1300002P16, DDBDRAFT_0219349, DDBDRAFT_0219924, DDB_0219349, DDB_0219924, hmgCoA, Hmgcs1, mHS, Mt3h3mg

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	HMGCS2	3158	P54868
	HMGCS2	15360	P54869
	HMGCS2	24450
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human HMGCS2 Antikörper:

anti-Mouse (Murine) HMGCS2 Antikörper:

anti-Rat (Rattus) HMGCS2 Antikörper:

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Verknüpfte Pathways mit anti-HMGCS2 Antikörper

Regulation of Lipid Metabolism by PPARalpha

Weitere Produktkategorien zu HMGCS2 Antikörper

Am meisten referenzierte anti-HMGCS2 Antikörper

Cow (Bovine) Polyclonal HMGCS2 Primary Antibody für WB - ABIN2776880 : Bouchard, Robert, Vinarov, Stanley, Thompson, Morris, Leonard, Quant, Hsu, Boneh, Boukaftane, Ashmarina, Wang, Miziorko, Mitchell: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients. in Pediatric research 2001 (PubMed)
Show all 3 Pubmed References

Weitere Antikörper gegen HMGCS2 Interaktionspartner

Human 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Interaktionspartner

Canonical pathway analysis, using Ingenuity Pathway Analysis software, revealed that the only genes in the "superpathway of cholesterol biosynthesis" were Idi1 (upregulated) and Hmgcs2 (downregulated). The Idi1 and Hmgcs2 genes have regulatory roles in atrial lipotoxic myopathy associated with atrial enlargement
Our data also suggested that apart from heart, the expression of HMGCS2 was also different in kidney and spleen between control and STZ treated mice. In conclusion, The HMGCS2 molecule may potentially be involved in T1D induced cardiac dysfunction.
several nutrients as well as specific nutritional related hormonal conditions are able to affect significantly HMGCS2 gene expression.
miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma
this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha), resulting in Src expression and activation in a metabolically independent manner
HMGCS2 shares with ketone bodies common features in autophagic clearance of APP, suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy.
High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy.
FABP7 and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast
In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21).
An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.
Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression
The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2.

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Interaktionspartner

To elucidate the relationship between HMGCS2 and NF-kB, we tested inhibited and over-expressed NF-kB. We found that NF-kB acted as a positive regulator for HMGCS2 under ketosis treatment conditions.
It is a key enzyme for catalyzing b-hydroxybutyric acid production, and observed in early Alzheimer's disease.And a hepatic inflammatory factor, IL-6 enhances ketogenesis through HMGCS2 signaling activation by p38/NF-kB p65.
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b.
HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8-/- mice.

HMGCS2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) Antikörper
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2) Antikörper
hydroxymethylglutaryl-CoA synthase (mvaS) Antikörper
hydroxymethylglutaryl-CoA synthase (CNC05080) Antikörper
hydroxymethylglutaryl-coa synthase (HMCS1) Antikörper
hydroxymethylglutaryl-CoA synthase (hgsA) Antikörper
hydroxymethylglutaryl-CoA synthase (MFER_RS00425) Antikörper
hydroxymethylglutaryl-CoA synthase (LOC100285783) Antikörper
3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2 (ECU10_0510) Antikörper
3-hydroxy-3-methylglutaryl-CoA synthase 2 (Eint_100450) Antikörper
3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2) Antikörper

1300002P16 Antikörper
DDBDRAFT_0219349 Antikörper
DDBDRAFT_0219924 Antikörper
DDB_0219349 Antikörper
DDB_0219924 Antikörper
hmgCoA Antikörper
Hmgcs1 Antikörper
mHS Antikörper
Mt3h3mg Antikörper

Bezeichner auf Proteinebene für HMGCS2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) , HMG-CoA synthase , hydroxymethylglutaryl-CoA synthase, mitochondrial , 3-hydroxy-3-methylglutaryl coenzyme A synthase , 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) , hydroxymethylglutaryl-CoA synthase 2 , hydroxymethylglutaryl-CoA synthase, mitochondrial-like , hydroxymethylglutaryl-CoA synthase , hydroxymethylglutaryl-coa synthase , GRMZM2G106263 , putative hydroxymethylglutaryl-CoA synthase family protein , 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2 , 3-hydroxy-3-methylglutaryl-CoA synthase 2 , 3-hydroxy-3-methylglutary-Coenzyme A synthase 2

GENE ID	SPEZIES
3158	Homo sapiens
15360	Mus musculus
100343479	Oryctolagus cuniculus
100449449	Pongo abelii
100484975	Ailuropoda melanoleuca
2798767	Listeria monocytogenes serotype 4b str. F2365
3256225	Cryptococcus neoformans var. neoformans JEC21
7446804	Thalassiosira pseudonana CCMP1335
8626645	Dictyostelium discoideum AX4
9961791	Methanothermus fervidus DSM 2088
100285783	Zea mays
100059971	Equus caballus
100581170	Nomascus leucogenys
859815	Encephalitozoon cuniculi GB-M1
9699436	Encephalitozoon intestinalis ATCC 50506
24450	Rattus norvegicus
503684	Bos taurus
424380	Gallus gallus
607923	Canis lupus familiaris
397673	Sus scrofa
100727078	Cavia porcellus

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Show all anti-3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Antikörper with Pubmed References

Human 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Interaktionspartner

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (Mitochondrial) (HMGCS2) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with HMGCS2

Bezeichner auf Proteinebene für HMGCS2