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anti-Human HMGCS2 Antikörper:
anti-Mouse (Murine) HMGCS2 Antikörper:
anti-Rat (Rattus) HMGCS2 Antikörper:
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Cow (Bovine) Polyclonal HMGCS2 Primary Antibody für WB - ABIN2776880
Bouchard, Robert, Vinarov, Stanley, Thompson, Morris, Leonard, Quant, Hsu, Boneh, Boukaftane, Ashmarina, Wang, Miziorko, Mitchell: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients. in Pediatric research 2001
Show all 3 Pubmed References
FLAKY POLLEN1 is required for organelle development in tapetal cells and pollen coat formation. [FKP1]
miR (zeige MLXIP Antikörper)-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma
this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha (zeige PPARA Antikörper)), resulting in Src (zeige SRC Antikörper) expression and activation in a metabolically independent manner
HMGCS2 shares with ketone bodies common features in autophagic clearance of APP (zeige APP Antikörper), suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy.
High expression of either HSD17B2 (zeige HSD17B2 Antikörper) or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy.
FABP7 (zeige FABP7 Antikörper) and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast
In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21 (zeige FGF21 Antikörper)).
An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL (zeige HMGCL Antikörper) with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.
Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 (zeige FGF21 Antikörper) expression
Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc (zeige MYC Antikörper)-mediated repression of the key metabolic gene HMGCS2.
It is a key enzyme for catalyzing b-hydroxybutyric acid production, and observed in early Alzheimer's disease.And a hepatic inflammatory factor, IL-6 (zeige IL6 Antikörper) enhances ketogenesis through HMGCS2 signaling activation by p38 (zeige CRK Antikörper)/NF-kB p65.
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3 (zeige ANGPTL3 Antikörper))-lipoprotein lipase (LPL (zeige LPL Antikörper))pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b (zeige STAT5B Antikörper).
HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8 (zeige KRT8 Antikörper)-/- mice.
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
, HMG-CoA synthase
, hydroxymethylglutaryl-CoA synthase, mitochondrial
, 3-hydroxy-3-methylglutaryl coenzyme A synthase
, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
, hydroxymethylglutaryl-CoA synthase 2
, hydroxymethylglutaryl-CoA synthase, mitochondrial-like
, hydroxymethylglutaryl-CoA synthase
, hydroxymethylglutaryl-coa synthase
, putative hydroxymethylglutaryl-CoA synthase family protein
, 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2
, 3-hydroxy-3-methylglutaryl-CoA synthase 2
, 3-hydroxy-3-methylglutary-Coenzyme A synthase 2