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3.2908103 | ABIN2774309 | WB | Rabbit | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
3.2908103 | ABIN2776928 | WB | Rabbit | Middle Region | Anmelden zum Anzeigen | Polyclonal | 2 | |||
1 | ABIN1100101 | WB | Rabbit | AA 284-333 | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Argininosuccinate Lyase (ASL) Antikörper |
Epitop | N-Term Alternativen |
Reaktivität | Rind (Kuh), Hund, Ziege, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Yeast (Saccharomyces cerevisiae), Zebrafisch (Danio rerio) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Unkonjugiert Alternativen |
Applikation |
Western Blotting (WB)
Alternativen
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1 Publikation vorhanden |
Hersteller | Anmelden zum Anzeigen |
ProduktdetailsAntigendetails Anwendungsinformationen Handhabung Referenzen Bilder |
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Blocking Peptide | Zu diesem Produkt passt das Blocking Peptide ABIN973512. |
Sequenz | GATAGKLHTG RSRNDQVVTD LRLWMRQTCS TLSGLLWELI RTMVDRAEAE |
Homologie | Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 100% |
Produktmerkmale | This is a rabbit polyclonal antibody against ASL. It was validated on Western Blot using a cell lysate as a positive control. |
Reinigung | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human ASL |
AntigendetailsProduktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | ASL (ASL Antibody Abstract) |
Hintergrund |
ASL is a member of the lyase 1 family. The protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in its gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency.This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. Alias Symbols: ASAL Protein Interaction Partner: WDYHV1, ASL, GINS4, NCDN, TUFM, PDHA1, NEDD8, HK1, GDI1, BAG3, OVGP1, HMOX1, FBP1, CSNK2A2, UBC, QARS, Protein Size: 464 |
Molekulargewicht | 52 kDa |
Gen-ID | 435 |
NCBI Accession | NM_000048, NP_000039 |
UniProt | P04424 |
Pathways | Response to Growth Hormone Stimulus |
AnwendungsinformationenProduktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben |
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Applikationshinweise | Optimal working dilutions should be determined experimentally by the investigator. |
Kommentare |
Antigen size: 464 AA |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Konservierungsmittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freeze-thaw cycles. |
Lagerung | -20 °C |
Informationen zur Lagerung | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
ReferenzenProduktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Produkt verwendet in: |
Trevisson, Salviati, Baldoin, Toldo, Casarin, Sacconi, Cesaro, Basso, Burlina: "Argininosuccinate lyase deficiency: mutational spectrum in Italian patients and identification of a novel ASL pseudogene." in: Human mutation, Vol. 28, Issue 7, pp. 694-702, 2007 |
BilderProduktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben |
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Bilder des Herstellers |