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These results suggest that the RBBP6-3 isoform may be involved in promoting apoptosis in cancerous cells.
RBBP6 is a candidate gene for myeloproliferative neoplasms (MPNs) susceptibility in a subset of pedigrees with familial MPN (zeige PRSS27 ELISA Kits).
High expression levels of RBBP6 and high apoptosis levels were found in HIV-associated nephropathy (HIVAN) cases. This direct association between RBBP6 expression and apoptosis levels suggests that RBBP6 play a role in HIVAN pathogenesis.
RBBP6 prevents DNA damage by destabilizing the transcriptional repressor ZBTB38 (zeige ZBTB38 ELISA Kits).
RBBP6 gene variants are associated with glioma and contribute to glioma susceptibility
implicate RBBP6 and iso3 as novel regulators of 3' processing, especially of RNAs with AU-rich 3' UTRs.
these findings suggest that RBBP6 isoform 3 is a cell cycle regulator and may be deregulated in carcinogenesis
AGO2 (zeige EIF2C2 ELISA Kits), PACT and TRBP (zeige TARBP2 ELISA Kits) are required for the efficient functioning of Dicer (zeige DICER1 ELISA Kits) in cells
Taken together with the structural similarities to U-box-containing proteins, our data suggest that RBBP6 plays a role in chaperone-mediated ubiquitination and possibly in protein quality control.
RBBP6 may be involved in the degradation of p53 (zeige TP53 ELISA Kits), thereby enhancing cell proliferation and inhibiting apoptosis in lung cancer.
P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression
the PACT-p53 (zeige TP53 ELISA Kits) interaction plays a critical role in embryonic development and tumorigenesis and identify PACT as a member of negative regulators of p53 (zeige TP53 ELISA Kits).
Mapped six genes (EIF4G3, HSP90 (zeige HSP90AB1 ELISA Kits), RBBP6, IL8 (zeige IL8 ELISA Kits), TERT (zeige TERT ELISA Kits), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.
E3 ubiquitin-protein ligase RBBP6
, RB-binding Q-protein 1
, p53-associated cellular protein of testis
, proliferation potential-related protein
, protein P2P-R
, retinoblastoma-binding Q protein 1
, retinoblastoma-binding protein 6
, retinoblastoma binding protein 6
, retinoblastoma-binding protein 6-like