Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
The three consanguineous Egyptian anophthalmia patients carry a novel homozygous c.543+3A>G mutation (IVS2+3A>G) in RAX.
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
Mutations in the newly identified RAX regulatory sequence are not a frequent cause of micro/anophthalmia.
Deletion of Rax in the eye generated loss of central visual pathways and the suprachiasmatic nucleus was absent.
the role of Rax in the early stages of hypothalamic development
Rax and Crx (zeige CRX Proteine) cooperatively transactivate Rhodopsin (zeige RHO Proteine) and cone opsin (zeige RHO Proteine) promoters and an optimum Rax expression level to transactivate photoreceptor gene expression exists.
This study provided evidence that Rax is required for the normal differentiation and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cerebrospinal fluid-hypothalamus barrier.
miR (zeige MLXIP Proteine)-29b mediated ethanol neurotoxicity through the SP1 (zeige SP1 Proteine)/RAX/PKR (zeige EIF2AK2 Proteine) cascade.
our study illustrates that Rax is required in ARC (zeige NOL3 Proteine)/VMH progenitors to specify neuronal phenotypes within this hypothalamic brain region.
This study demonistrated that the RAX homeoprotein interacts with embryonic enhancer locus for photoreceptor Otx2 (zeige OTX2 Proteine) transcription to transactivate Otx2 (zeige OTX2 Proteine), mainly in the final cell cycle of retinal progenitors
subpopulations of retinal neurons can be generated in retinal explant cultures from grafted mouse ES cells ectopically expressing the transcription factor Rx/rax
These findings in mice and Drosophila illustrate the importance of RAX for embryonic development.
Development of auxiliary eye structures does not depend on retina-specific gene expression or retinal morphogenesis. Lens formation involves beta-catenin (zeige CTNNB1 Proteine) expression in the head surface ectoderm.
We then show that Rx controls proliferation within the MBNB clones independently of Tailless (Tll (zeige NR2E1 Proteine)) and Prospero (zeige PROX1 Proteine) (Pros), and does not regulate the expression of other key regulators of MB development, Eyeless (Ey) and Dachshund (Dac (zeige FBXW4 Proteine)). Our data support that the role of Rx in forebrain development is conserved between vertebrates and fly.
Drx is not required for establishment of the drosophila visual system.
This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma.
retina and anterior neural fold homeobox protein
, retinal homeobox protein Rx
, double-stranded RNA-binding protein A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog B
, Rx/rax homeoprotein
, eyeless 1
, retinal homeobox protein Rx1
, retinal homeobox protein Rx2
, retina and anterior neural fold homeobox
, retinal homeobox
, drosophila Rx