Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human DICER1 Protein expressed in HEK-293 Cells - ABIN2719477
Zhang, Li, Deng, Liu, Chen, Tang, Wang, Cao, Fang, Wen, Xu, Chen, Shi, Li, Xie, Tang: Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. in Nucleic acids research 2016
The DICER mediates the recruitment of the methyltransferase MMSET to the DNA damage site.
DICER1 is a driver of pediatric thyroid nodules, and DICER1-mutated papillary thyroid carcinoma may represent a distinct class of low-risk malignancies.
Testing for DICER1 mutations may be beneficial for distinguishing between ovarian Sertoli-Leydig cell tumors subtypes and from other tumors in the ovarian sex cord-stromal tumors category, as well as other primary tumors of the ovary
DICER rs3742330 AG+GG genotype was associated with more advanced T stage compared to AA genotype ( P=0.009). More patients with XPO5 rs2257082 CC genotype had poorly differentiated tumors compared with CT+TT genotype carriers..), carriers of RAN rs14035 CC genotype had higher three-year OS rate than carriers of CT+TT genotype (adjusted HR 3.174; 95% CI 1.010, 9.973; P=0.048).
DICER1 hot-spot mutation is the key-driving event in a subset of gynandroblastomas containing components of Sertoli-Leydig cell tumour and juvenile granulosa cell tumour
We tested the role of microRNAs in hepatic stellate cells by hepatic stellate cell-specific Dicer deletion. Although Dicer deletion decreased microRNA expression in hepatic stellar cells and altered the expression of select genes, it only exerted negligible effects on hepatic stellate cells activation and liver fibrosis
Data indicate that Dicer protein was specifically overexpressed in ovarian tumor stroma
Different genotypes frequency of DICER1 (rs12323635, rs1057035, rs13078 and rs3742330) were determined by sequencing method in 385 infertile men and 120 fertile controls. It was found that CC genotype (P = 0.000) and C allele (P = 0.0) of rs1057035 T > C polymorphism were associated with idiopathic male infertility (azoospermia).
DICER1-AS1 regulates the proliferation, invasion and autophagy of osteosarcoma via miR-30b/ATG5 axis.
neither likely pathogenic nor pathogenic variants in DICER1 appear to play a major role in transposition of the great arteries.
first report of DICER1 mutations in pulmonary blastoma.
Decreased argonaute 2 and dicer1 in peripheral blood mononuclear cells from War Veterans with post-traumatic stress disorder leads to diminished miRNA resulting in elevated inflammation.
The activation of Dicer suppressed the production of TNFalpha. These results suggested that Dicer can balance the production of TNFalpha, and thus may serve as a regulator of the immune response in patients with RA.
Dicer efficiently suppresses the replication of adenovirus via cleavage of adenovirus-encoding small RNAs.
The present study demonstrates that hypoxia-induced downregulation of Dicer serves as key mechanism in the maintenance of the hypoxic response in HCC and that prevention of hypoxic suppression of Dicer not only alleviates hypoxia-induced upregulation of HIF1a and HIF2a and other key hypoxia-responsive/HIF target genes, but also inhibits hypoxia-induced metastatic phenotypes such as EMT and increased cell motility.
two cases with DICER1 mutations were found to have lung cysts preceding the diagnosis of pathogenesis of pleuropulmonary blastoma
Decreased Dicer expression was found in chronic lymphocytic leukemia patients with chromosomal deletions.
Most neoplasms in the syndrome have been shown to harbor biallelic pathogenic variants in DICER1, usually a germline loss-of-function pathogenic variant in one allele that can occur in any domain and a tumor-specific pathogenic somatic variant in exons encoding the RNase IIIb domain of the second allele
Describe familial HCC associated with a novel DICER1 germline mutation and altered liver zonation. Familial and sporadic HCCs carrying DICER1 mutations are associated with CTNNB1 mutation and characterized by a reduced expression of specific mature miRNAs.
Findings imply that Dicer inhibits clear cell renal cell carcinoma (ccRCC) metastasis and may serve as promising prognostic biomarkers for ccRCC patients.
Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.
The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.
Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Dicer1, Dcr-1 homolog
, endoribonuclease Dicer
, dicer 1, ribonuclease type III
, double-stranded RNA-specific endoribonuclease type III
, double-strand-specific ribonuclease mDCR-1
, dicer 1, double-stranded RNA-specific endoribonuclease
, helicase MOI
, helicase with RNAse motif
, dsRNA-specific ribonuclease