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Human Polyclonal DICER1 Primary Antibody für IHC, IHC (p) - ABIN268305
Doi, Zenno, Ueda, Ohki-Hamazaki, Ui-Tei, Saigo: Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. in Current biology : CB 2003
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Human Polyclonal DICER1 Primary Antibody für IHC, IHC (p) - ABIN4305208
Montenegro, Romero, Kim, Tarca, Draghici, Kusanovic, Kim, Lee, Erez, Gotsch, Hassan, Kim: Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition. in The Journal of pathology 2008
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Human Polyclonal DICER1 Primary Antibody für IP, WB - ABIN438466
Tan, Garchow, Liu, Metzler, Kiriakidou: Clarifying mammalian RISC assembly in vitro. in BMC molecular biology 2011
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Mammalian Monoclonal DICER1 Primary Antibody für WB - ABIN1304616
Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014
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Human Polyclonal DICER1 Primary Antibody für ChIP, IP - ABIN577054
Wang, McAllister, Bailey, Scott, Hendley, Leach, Ghosh: Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. in PLoS ONE 2014
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Human Polyclonal DICER1 Primary Antibody für ICC, IF - ABIN438467
Huang, Chuang, Hao, Talbot, Sen, Trink, Sidransky, Ratovitski: Phospho-?Np63? is a key regulator of the cisplatin-induced microRNAome in cancer cells. in Cell death and differentiation 2011
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Human Polyclonal DICER1 Primary Antibody für WB - ABIN223376
Edinger, Coronnello, Bodnar, LaFramboise, Benos, Ho, Johnson, Butterworth, Bhalla, Labarca: Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport. in Journal of the American Society of Nephrology : JASN 2014
Human Monoclonal DICER1 Primary Antibody für ELISA, WB - ABIN525145
Chen, Li, Lin, Yang, Chien, Syu, Lo: Cleavage of Dicer protein by I7 protease during vaccinia virus infection. in PLoS ONE 2015
Human Polyclonal DICER1 Primary Antibody für ELISA, FACS - ABIN4305211
McNamara, Andrechek, Wang, Viles, Rempel, Gilboa, Sullenger, Giangrande: Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. in Nature biotechnology 2006
Loss of Dicer1 expression is associated with ovarian tumor cells originating in the fallopian tube stroma.
Dicer is crucial for maintenance of adult dopaminergic neurons, whereas a stimulation of microrna production can promote neuronal survival.
Data show that Dicer1(Flox/-) mice histologically and genetically resemble human angiosarcoma.
These findings reveal that Dicer, through its production of mature miRNAs, plays a key role in the maintenance of monosynaptic sensory-motor circuits.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
Lack of Dicer leads to oxidative stress, cytosolic acidification, upregulated NHE1 (zeige SLC9A1 Antikörper) expression and activity as well as swelling of CD4 (zeige CD4 Antikörper)+ T cells, functions all reversed by miR (zeige MLXIP Antikörper)-15b or miR (zeige MLXIP Antikörper)-200b.
Results show that elevated miR (zeige MLXIP Antikörper)-15b as an early response to Dicer depletion silenced Pim-1 (zeige PIM1 Antikörper) kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer-deleted adult hearts result in marked amelioration of cardiac dysfunction.
Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...
Dicer maintains the identity and function of proprioceptive sensory neurons. Results suggest that Dicer and, most likely by extension, microRNAs are crucially important for maintaining proprioception. Additionally, this study hints at the larger question of how neurons maintain their functional and molecular specificity.
this study shows that Dicer deficiency differentially impacts microglia of the developing and adult brain
Describe familial HCC (zeige FAM126A Antikörper) associated with a novel DICER1 germline mutation and altered liver zonation. Familial and sporadic HCCs (zeige HCCS Antikörper) carrying DICER1 mutations are associated with CTNNB1 (zeige CTNNB1 Antikörper) mutation and characterized by a reduced expression of specific mature miRNAs.
Findings imply that Dicer inhibits clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC) metastasis and may serve as promising prognostic biomarkers for ccRCC patients.
Our results suggest that, in contrast to FOXL2 (zeige FOXL2 Antikörper) mutations in adult granulosa cell tumours (A-GCTs), DICER1 mutations in Sertoli-Leydig cell tumours (SLCTs) might be more useful for prognosis than for diagnosis.
Low Dicer status was associated with poor prognosis in ovarian cancer, otorhinolaryngological tumors and ematological malignancies.
Study identified nonsense germ-line and missense somatic mutations in DICER1 causing a truncated protein at the IIIb domain level that segregate within a family affected with Dicer1 syndrome.
Data suggest that DICER plays a pleiotropic role in glioma stem-like cells, modulating the growth properties of glioma tumors arising from these cells and their response to DNA damage-inducing agents, leading to formation of larger tumors that are more sensitive to radiation.
validate the results of the aforementioned animal study and demonstrate downregulation of DICER1 gene and abnormal miRNA profile in myelodysplastic syndrome
We found that inhibition of DICER processing of miR (zeige MLXIP Antikörper)-544 through the use of a small molecule abolished miR (zeige MLXIP Antikörper)-544 function in regulating adaptation of breast cancer cells to hypoxic stress.
Data show that the expression of miRNAs and Dicer1 were downregulated in cells lines expressing HTLV-I HBZ (zeige HBZ Antikörper) protein (HBZ (zeige HBZ Antikörper)) as well as in fresh CD4 (zeige CD4 Antikörper) (+) cells from acute adult T cell Leukemia (ATL) patients.
the DICER rs1057035 TT genotype and DROSHA (zeige DROSHA Antikörper) rs644236 CC genotype were associated with the development of GD and the differentiation between GD and HD, respectively. The expression levels of DICER and DROSHA (zeige DROSHA Antikörper) genes were low in AITD and differed depending on the intractability of GD and the severity of HD, respectively.
Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.
The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.
Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Dicer1, Dcr-1 homolog
, endoribonuclease Dicer
, dicer 1, ribonuclease type III
, double-stranded RNA-specific endoribonuclease type III
, double-strand-specific ribonuclease mDCR-1
, dicer 1, double-stranded RNA-specific endoribonuclease
, helicase MOI
, helicase with RNAse motif
, dsRNA-specific ribonuclease