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In plasma, but not CSF (zeige CSF2 Proteine), the bivariate MCP4 (CCL13)/ MCP1(CCL2 (zeige CCL2 Proteine)) ratio is ca. twofold elevated in PTSD patients compared with healthy controls.
CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing
The reduction of circulating levels of MCP-4, eotaxin-3 (zeige CCL26 Proteine), and MIP-1beta (zeige CCL4 Proteine) could be one of the mechanisms by which bariatric surgery contributes to the reduction of cardiovascular risk in these patients.
CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis.
identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3 (zeige CCL3 Proteine), CCL4/CCL4L1 (zeige CCL4 Proteine)/CCL4L2, CD160 (zeige CD160 Proteine), IFNG (zeige IFNG Proteine), NR4A3 (zeige NR4A3 Proteine) and XCL1 (zeige XCL1 Proteine)/XCL2 (zeige XCL2 Proteine)) were analyzed in 127 kidney biopsies
CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli.
Data suggest that CCL13 binds to several chemokine (zeige CCL1 Proteine) receptors (CCR1, CCR2 (zeige CCR2 Proteine), and CCR3 (zeige CCR3 Proteine)), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW]
MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease.
E(2) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-alpha (zeige TNF Proteine)-induced MMP-3 (zeige MMP3 Proteine) production, and CCL13 overproduction, subsequently resulting in the disease progression of RA.
Data show that, for the small macrophages in COPD (zeige ARCN1 Proteine), increased transcript and protein levels for CCL2 (zeige CCL2 Proteine), CCL7 (zeige CCL7 Proteine), CCL13 and CCL22 (zeige CCL22 Proteine) with a more than 100-fold increase for CCL13 mRNA.
deletion of the gene encoding MMCP-4 (Mcpt4), markedly reduced late, but not early, infarct size by suppressing IGF-1 (zeige IGF1 Proteine) degradation and, consequently, diminished cardiac dysfunction and adverse structural remodeling
Data indicate that a second-degree burn injury can initiate an immediate novel zonal degranulation of mast cell throughout all skin layers and a disruption of the epidermal tight junctions dependent on the nonredundant presence of mMCP4 and mMCP5 (zeige CMA1 Proteine).
these results support the conclusion that mast cells can contribute to the initial lung injury induced by bleomycin through release of the MCPT4 chymase (zeige CMA1 Proteine).
Mast cell chymase (zeige CMA1 Proteine) degrades the alarmins heat shock protein 70 (zeige HSP70 Proteine), biglycan (zeige BGN Proteine), HMGB1 (zeige HMGB1 Proteine), and interleukin-33 (IL-33 (zeige IL33 Proteine)) and limits danger-induced inflammation.
Data from Mcp-4 (mast cell protease 4) knockout mice suggest Mcp-4 plays a pivotal role in the dynamic (in vivo and in vitro) conversion of systemic Big-endothelin-1 (zeige EDN1 Proteine) to endothelin-1 (zeige EDN1 Proteine) (1-31).
MCs (zeige SMCP Proteine) exert protective functions after trauma, at least in part via mMCP-4, by suppressing exacerbated inflammation via their proteases.
The effects of interactions between mMCP-4 and TNF (zeige TNF Proteine) in vivo by analyzing the features of a classic model of polymicrobial sepsis, were assessed.
mMCP-4 plays two different roles in the pathogenesis of experimental BP, by both activating MMP-9 (zeige MMP9 Proteine) and by cleaving BP180 (zeige COL17A1 Proteine), leading to injury of the hemidesmosomes and extracellular matrix of the basement membrane zone.
mMCP-4-deficient mice but not to mMCP-5 (zeige CMA1 Proteine)-deficient mice revealing nonredundant actions for these two MC proteases in a model of innate inflammatory injury with remodeling.
MCP-4 contributes locally to the aggravation of glomerulonephritis by mediating a variety of proinflammatory effects.
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis.
C-C motif chemokine 13
, monocyte chemoattractant protein 4
, monocyte chemotactic protein 4
, new CC chemokine 1
, small inducible cytokine subfamily A (Cys-Cys), member 13
, small-inducible cytokine A13
, monocyte chemotactic protein-4
, serosal mast cell protease