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Results suggest that sequence variants in TNC and COL5A1 genes are associated with superficial digital flexor tendinopathy in TB racehorses. In
In addition, we found that Tn-expressing colorectal cancers (CRC (zeige CALR Proteine)) cell lines had either loss-of-function mutations in Cosmc (zeige C1GALT1C1 Proteine) or reversible Tn antigen expression, which was not caused by the deficiency of T-synthase (zeige C1GALT1 Proteine) activity
The results demonstrated that ANX2 (zeige ANXA2 Proteine) and stromal tenascin C regulated invasion in addition to stemness and anoikis resistance, which are crucial for metastasis in the progression of pancreatic ductal adenocarcinoma.
Intratumor stromal expression of tenascin-C (TN-C) is a strong prognostic indicator in locally advanced unresectable (UR-LA) pancreatic ductal adenocarcinoma (PDAC) patients with resection after chemoradiotherapy (CRT (zeige SLC6A8 Proteine)).
this study shows that tenascin C is increased in vitiligo (zeige MITF Proteine) in lesional areas only in the acral sites
Data indicate three sites within tenascin-C that directly and cooperatively interact with toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)).
Results identify tenascin-C as an endogenous danger signal that is upregulated in systemic sclerosis and drives TLR4 (zeige TLR4 Proteine)-dependent fibroblast activation, and by its persistence impedes fibrosis resolution.
Both fetal Tn-C variants may represent novel biomarkers that are capable of estimating both pulmonary vascular remodeling and right ventricular load.
high TNC expression correlates with worse prognosis for lung adenocarcinoma and has a role in lung cancer progressoin
Decellularized lung scaffolds treated with FBN-2 (zeige FBN2 Proteine) and TN-C prior to re-epithelialization supported greater epithelial proliferation and tissue remodeling.
Immunohistochemical analysis shows that the unique association between the CD44 (zeige CD44 Proteine)+/CD24low/- phenotype and the pronounced production of tenascin C may have a prognostic potential, prospectively indicating the inefficiency of neoadjuvant polychemotherapy (PCT (zeige UROD Proteine)), in particular that with platinum derivatives, which is used for the standard treatment of triple-negative BC.
ATF3 promotes macrophage migration and reverses M1polarized macrophages to the M2 phenotype by upregulation of TNC via the Wnt/betacatenin signaling pathway.
housing of TnC-/- mice in enriched environment abolished hyperlocomotion, led to faster habituation to novel environment, strengthened the grasp of fore limbs and partially improved movement coordination, while the swimming ability remained deficient
The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack tenascin-C, the informational content stored by synaptic plasticity is not the same.
Study suggests that tenascin-C (TnC) contributes to the regulation of structural plasticity in the cerebellum and that interactions between TnC and matrix metalloproteinase 9 (zeige MMP9 Proteine) are likely to be important for these processes to occur.
the exact role of TNC in primary tumor growth
A deficiency of tenascin C interferes with Th1 (zeige HAND1 Proteine) and Th17 cells, protecting animals from experimental autoimmune encephalomyelitis.
Tenascin-C may be an important mediator in the development of brain edema and blood-brain barrier disruption following subarachnoid hemorrhage, mechanisms for which may involve MAPK (zeige MAPK1 Proteine)-mediated MMP-9 (zeige MMP9 Proteine) induction and ZO-1 (zeige TJP1 Proteine) degradation
TN-C aggravates autoimmune myocarditis by driving the dendritic cell activation and Th17 differentiation via toll-like receptor 4 (zeige TLR4 Proteine).
TNC supports the stress-induced expression of extracellular matrix that reinforce the aorta and the stress-induced excessive inflammatory response in the aorta.
TNC does not appear to contribute directly to outflow resistance in the eye.
TNC could be a potential candidate gene for meat quality traits in pigs.
tenascin binds to fibronectin (zeige FN1 Proteine) at a cryptic binding site
Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers. Increase of rat soleus muscle loading modifies basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C.
tenascin-C is part of a specialized extracellular matrix in the region of the horizontal myoseptum that influences the growth of motor axons
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
, tenascin C (hexabrachion)
, GP 150-225
, glioma-associated-extracellular matrix antigen
, hexabrachion (tenascin)
, myotendinous antigen
, tenascin-C isoform 14/AD1/16