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Human Monoclonal PRDM1 Primary Antibody für ChIP, ELISA - ABIN153174
John, Clements, Russell, Garrett-Sinha: Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1. in The Journal of biological chemistry 2008
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Human Monoclonal PRDM1 Primary Antibody für ELISA, IHC (fro) - ABIN314190
Liu, Leboeuf, Shi, Li, Wang, Shen, Garcia, Shen, Chen, Janin, Chen, Zhao: Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma. in Blood 2007
Show all 11 Pubmed References
Human Monoclonal PRDM1 Primary Antibody für ELISA, ICC - ABIN314189
Ohinata, Payer, OCarroll, Ancelin, Ono, Sano, Barton, Obukhanych, Nussenzweig, Tarakhovsky, Saitou, Surani: Blimp1 is a critical determinant of the germ cell lineage in mice. in Nature 2005
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Human Monoclonal PRDM1 Primary Antibody für ICS, IHC (p) - ABIN2688853
Chan, Chiang, Tsai, Su, Chen, Hou, Lin: Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in dendritic cell homeostatic development and function. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Monoclonal PRDM1 Primary Antibody für IHC (fro), IF - ABIN534050
Chang, Cattoretti, Calame: The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development. in Mechanisms of development 2002
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Human Monoclonal PRDM1 Primary Antibody für IHC, WB - ABIN2668849
Valer Corellano: [Malignant fibrous histiocytoma of soft tissues: early report of 10 cases]. in Medicina clínica 1991
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Human Polyclonal PRDM1 Primary Antibody für IHC (p), WB - ABIN541569
Angelin-Duclos, Cattoretti, Lin, Calame: Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. in Journal of immunology (Baltimore, Md. : 1950) 2000
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Human Monoclonal PRDM1 Primary Antibody für ELISA, WB - ABIN1724737
Ancelin, Lange, Hajkova, Schneider, Bannister, Kouzarides, Surani: Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. in Nature cell biology 2006
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Human Polyclonal PRDM1 Primary Antibody für IF, WB - ABIN541568
Reimold, Iwakoshi, Manis, Vallabhajosyula, Szomolanyi-Tsuda, Gravallese, Friend, Grusby, Alt, Glimcher: Plasma cell differentiation requires the transcription factor XBP-1. in Nature 2001
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Human Monoclonal PRDM1 Primary Antibody für FACS - ABIN4897745
Kurioka, Ussher, Cosgrove, Clough, Fergusson, Smith, Kang, Walker, Hansen, Willberg, Klenerman: MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets. in Mucosal immunology 2015
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BLIMP1 (PRDM1)expression begins throughout the hypoblast at stage 1 and emerges in single primordial germ cell (PGC) precursors in the posterior epiblast at stage 2.
results suggest that Blimp-1 is degraded by the 26S proteasome and is recruited by FBXO11 in the fat body, which is important for determining pupation timing
Blimp-1 regulates the expression of genes involved in chitin deposition and F-actin organization during tracheal maturation.
The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
Blimp-1 gene is transcribed during prepupal development when the ecdysteroid titer is high, but the expressed mRNA degrades rapidly.
Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.
Expression of the M- and N-cadherins, previously implicated in driving adaxial cell migration, is largely unaffected by loss of Prdm1a function, suggesting that differential cadherin expression is not sufficient for adaxial cell migration
Prdm1a functions as both a transcriptional activator and repressor during neural crest development.
identify sox6 cis-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner
prdm1a expression is upregulated in the absence of Notch function, and inhibiting Notch signaling fails to rescue prdm1a mutants
prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons.
These results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton.
Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers, encodes the zebrafish homolog of Blimp-1
The transcriptional regulator Blimp-1 plays a role in the inception of Neural Crest progenitor fate through BMP signalling.
prdm1/blimp1 has roles in embryo patterning and organogenesis
prdm1 functions to promote the cell fate specification of both neural crest cells and sensory neurons
Transcription factor Prdm1 has been shown to be crucial for zebrafish forelimb development.
Absolutely critical for the proper induction of gene expression in the ectoderm and establishment of the apical ectodermal ridge.
Exprsssion of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch musle fibers with differing requirements for shh and Prdm1 activity.
Prdm1 promotes slow-twitch fibre differentiation by acting as a global repressor of fast-fibre-specific genes, as well as by abrogating the repression of slow-fibre-specific genes.
Blimp1 programs myoblasts to adopt the slow-twitch fiber fate and can repress the expression of fast muscle-specific myosin light chain, mylz2.
Study demonstrated that EGFR activation could upregulate the BLIMP1 gene transcription via the PKC, p38, and ERK pathways in keratinocytes. Besides, proteasome and lysosome contribute to the maintenance of BLIMP1 protein stability.
The binding of bio-tagged NFATc1/alphaA to a regulatory region of the Prdm1 gene indicates Prdm1 as a direct target of NFATc1/alphaA which, when overexpressed in centrocytic B cells impairs plasma cell formation.
The authors herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients.
Studied role of PR/SET domain 1 (PRDM1) protein in colon cancer; found that PRDM1beta acts as a tumor-suppressor gene in colon tumor organoids, probably by acting downstream of p53. The study also shows It modifies the expression of stem cell related genes, inhibits colon epithelial cell proliferation, and is associated with good survival in colon cancer patients.
Data found that intratumoral hypoxia, which is an inevitable feature of advanced human pancreatic ductal adenocarcinoma, induces the expression of the pro-metastatic transcription factor Blimp1. The co-option of this master regulatory transcription factor is required for metastatic ability, and the molecular output of Blimp1 expression is the modulation of discrete hypoxia-induced gene expression programs.
Blimp1, Foxp1 and pStat3 are expressed in extranodal diffuse large B-cell lymphomas
In conclusion, aberrant coexpression of MYC and PRDM1/Blimp1alpha owing to genetic changes is responsible for the phenotype of plasmablastic lymphoma cases.
Blimp-1 binds to the promoters of PD-1 and TIGIT and positively regulates their expression in patients with acute myeloid leukemia.
the promoter hypermethylation of PRDM1 harbored a predominant role in the downregulation of PRDM1 expression, significantly affecting the biological behavior of tumor cells in EN-NK/T-NT.
Blimp-1 suppresses the transcription of CUL4A, resulting in the maintenance of the expression of Aiolos and Ikaros.
HSP70-Hrd1 axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants.
SOX2 repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase UTX to the SOX2 promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 has been shown to initiate human PGC specification, with its target PRDM1 suppressing mesendodermal genes
The interaction between c-Maf and RORgammat, and Blimp-1.
these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC-DLBCL patients.
PRDM1 was identified as a susceptibility gene for systemic sclerosis.
Data indicate that BTG2, MAP3K11, RPS6KA1 and PRDM1 as putative targets of microRNA miR-125b.
we identified MIR155HG and TERC to be transcriptionally downregulated by PRDM1 in two PRDM1-null NK-cell lines when it is ectopically expressed. These findings suggest that ZFAS1 and other dysregulated long non-coding RNAs may be involved in natural killer/T-cell lymphoma pathobiology through regulation of cancer-related genes, and loss-of-PRDM1 expression in natural killer/T-cell lymphomas tumorigenesis
identified the Prdm1 gene encoding the B lymphocyte-induced maturation protein 1 as a crucial negative regulator of human TH17 cell differentiation
B cell receptor signaling component, SYK, caused PAX5 tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 promoter by PAX5 was attenuated by this phosphorylation.
Depletion of PRDM1 in lung cancer cells promotes cellular invasion and anoikis resistance in vitro and lung metastasis in vivo.
Blimp1 regulates gene expression during trophoblast stem cell differentiation.
Overexpression of Blimp-1 in T cells promoted the formation of an anti-inflammatory cell-cytokine composition.
Mzb1-deficiency mimics, in part, the phenotype of Blimp1 deficiency, including the impaired secretion of IgM and the deregulation of Blimp1 target genes.
B lymphocyte-induced maturation protein 1 (Blimp1) expression defines a mammary stem cell subpopulation with unique functional characteristics.
Blimp1-dependent transcripts are enriched in spiral artery trophoblast giant cells.
Moreover, the authors showed that Sirt6, induced by RANKL-dependent NFATc1 expression, forms a complex with B lymphocyte-induced maturation protein-1 (Blimp1) to negatively regulate expression of anti-osteoclastogenic gene such as Mafb.
Posterior PRDM1 contributes more broadly to the developing fetal-maternal connection than previously recognized, and PRDM1 and STELLA, while overlapping in putative primordial germ cells, also co-localize in several other tissues
Blimp1 deficiency resulted in reduced suppressive ability of Tfr cells. This study identifies that Tfr cells are potent suppressors of immunity and are controlled by Blimp1.
Data show that TLR4-mediated up-regulation of Blimp-1 led to the down-regulation of NLRP12 expression in dextran sulfate sodium (DSS)-induced colitis.
Results established a molecular mechanism of TNF-a-induced osteoclasts differentiation, and provided insights into the potential contribution of Blimp1 in the regulation of osteoclastogenesis by TNF-a.
results show that the intersection of three or more transcription factors is required to correctly regulate the spatial and temporal features of Blimp1 enhancer expression
findings show that Prdm1 acts independently of Aire, a crucial transcription factor implicated in medullary thymic epithelial cells function; data highlight a previously unrecognized role for Prdm1 in regulating thymic epithelial function
role in natural antibody production by B-1 and B-1-derived plasma cells
Prdm1 repressed expression of the gene encoding cathepsin S (Ctss). Prdm1 deficiency in dendritic cells led to loss of appropriate regulation of Ctss expression in female mice and thereby modulated antigen presentation and the follicular helper T cell repertoire to contribute to autoimmunity in lupus.
Blimp1 is required to maintain a highly proliferative luminal subset necessary for mammary gland development and homeostasis.
Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1).
role of Blimp-1 as a critical regulator of CD4 dysfunction and links it to the CD8 T cell dysfunctionality observed in infected mice.
Contextual ablation of BLIMP-1 and p53 led to development of IgM-positive B-cell lymphoma with an aggressive phenotype, supported by c-Myc up-regulation, and accumulation of somatic mutations, as demonstrated by whole exome sequencing.
this study shows that IL-10 production during B-cell development is strongly correlated with the expression level of Prdm1
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
PR domain containing 1, with ZNF domain
, Blimp-1 protein
, B lymphocyte-induced maturation protein 1
, PR domain zinc finger protein 1
, PR domain-containing 1
, U boot
, B lymphocyte induced maturation protein 1
, PR domain zinc finger protein 1-like
, B-lymphocyte-induced maturation protein 1
, PRDI-binding factor-1
, beta-interferon gene positive-regulatory domain I binding factor
, B lymphocyte induced maturation protein
, PR domain containing 1 with ZNF domain
, PR domain-containing protein 1
, beta-interferon gene positive regulatory domain I-binding factor