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Human Polyclonal HOPX Primary Antibody für FACS, WB - ABIN655402
Kovárová, Plachy, Kosla, Trejbalová, ?ermák, Hejnar: Downregulation of HOPX controls metastatic behavior in sarcoma cells and identifies genes associated with metastasis. in Molecular cancer research : MCR 2013
Human Polyclonal HOPX Primary Antibody für ICC, IF - ABIN4319670
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis
The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90 (zeige HSP90 Antikörper)) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop (zeige STIP1 Antikörper)) is a useful prototype to study the fundamental molecular details about the Hop (zeige STIP1 Antikörper)-Hsp90 (zeige HSP90 Antikörper) interaction. Observed are conformational changes of the peptide and the protein receptor induced by binding. The binding free energy is 8.4 kcal/mol (zeige DUOXA1 Antikörper).
HOPX is functionally regulated by SCL (zeige KRT7 Antikörper) in hematoendothelial differentiation of mesoderm progenitor cells.
HOPX is a distinctive homeobox (zeige Lbx1 Antikörper) gene with characteristic clinical and biological implications and its expression is a powerful predictor of prognosis in AML (zeige RUNX1 Antikörper) patients.
HOPX has a role in the pathogenesis of skin cancers and skin diseases.
these data indicate that the disruption of the PrP(C (zeige PRNP Antikörper))-HOP (zeige STIP1 Antikörper) complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC (zeige CALR Antikörper)).
HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer.
Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis.
The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene.
Data show that binding of heat shock proteins Hsp70 (zeige HSP70 Antikörper) and Hsp90 (zeige HSP90 Antikörper) requires prior binding of Hop (zeige STIP1 Antikörper) protein to Hsp90 (zeige HSP90 Antikörper).
Analysis of the hematopoietic stem/progenitor cell pool in Hopx-/- mice demonstrated significantly reduced cell frequencies and impaired engraftment in competitive repopulation assays, thus providing functional validation of this positional candidate gene
Type I alveolar cells expressing Hopx manifest plasticity to regenerate type II alveolar cells in the lung.
Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 (zeige IL2 Antikörper) Expression.
Hopx integrates Bmp and Wnt (zeige WNT2 Antikörper) signaling by physically interacting with activated Smads and repressing Wnt (zeige WNT2 Antikörper) genes.
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.
HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure.
Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas (zeige FAS Antikörper)-induced apoptosis.
Hopx is required for the function of regulatory T cells induced by DCs and the promotion of DC-mediated T cell unresponsiveness in vivo.
Hdac2 (zeige HDAC2 Antikörper), Hopx, and Gata4 (zeige GATA4 Antikörper) coordinately regulate cardiac myocyte proliferation during embryonic development.
data show that Hop (zeige STIP1 Antikörper) can inhibit serum response factor-dependent transcriptional activation by recruiting histone deacetylase (HDAC (zeige HDAC1 Antikörper)) activity and can form a complex that includes HDAC2 (zeige HDAC2 Antikörper)
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene.
, lung cancer-associated Y protein
, not expressed in choriocarcinoma clone 1
, not expressed in choriocarcinoma protein 1
, odd homeobox 1 protein
, odd homeobox protein 1
, homeobox only domain
, homeobox-only protein
, homeodomain only protein
, odd homeobox 1
, global ischemia induced protein GIIG15B
, global ischemia-induced gene 15B protein
, global ischemia-induced protein 15B
, HOP homeobox