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Human Polyclonal GREM1 Primary Antibody für IHC (p), WB - ABIN390078
Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009
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Human Polyclonal GREM1 Primary Antibody für IHC (p), IHC - ABIN252810
Okamoto, Lezhava, Hosaka, Okamoto-Hosoya, Ochi: Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). in Journal of bacteriology 2003
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Human Polyclonal GREM1 Primary Antibody für WB - ABIN966222
Stabile, Mitola, Moroni, Belleri, Nicoli, Coltrini, Peri, Pessi, Orsatti, Talamo, Castronovo, Waltregny, Cotelli, Ribatti, Presta: Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. in Blood 2007
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Human Monoclonal GREM1 Primary Antibody für ELISA, WB - ABIN565294
Sha, Zhang, Zhang, Wan, Zhao, Li, Lang: Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis. in Fertility and sterility 2009
Human Polyclonal GREM1 Primary Antibody für IF (p), IHC (p) - ABIN687082
Wellbrock, Sheikhzadeh, Oliveira-Ferrer, Stamm, Hillebrand, Keyser, Klokow, Vohwinkel, Bonk, Otto, Streichert, Balabanov, Hagel, Rybczynski, Bentzien, Bokemeyer, von Kodolitsch, Fiedler: Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection. in PLoS ONE 2014
FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 (zeige BMP4 Antikörper) transcription, and activation of bmp antagonists, nog2 and grem1a.
Results suggest that the negative regulatory loops between BMP/Tbx2 (zeige TBX2 Antikörper) and Gremlin or Hey1 (zeige HEY1 Antikörper) are responsible for defining the territory of the pronephric nephron.
Gremlin encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition.
We conclude that gremlin promotes RPE (zeige RPE Antikörper) cell proliferation, migration and VEGF (zeige VEGFA Antikörper) production possibly via activating VEGFR2 (zeige KDR Antikörper)-Akt (zeige AKT1 Antikörper)-mTORC2 (zeige CRTC2 Antikörper) signaling. Gremlin could be a novel therapeutic target of ROP (zeige STXBP1 Antikörper) or other retinal vasoproliferation diseases.
Wild-type gremlin is able to bind broadly across the various regions of kidney in an heparin sulfate-dependent manner, with particularly intense binding to tubular structures in the renal cortex. In a model of chronic kidney disease, fibrotic changes in the kidney result in a loss of gremlin binding sites. Gremlin mutants with reduced affinity for heparin showed negligible binding under the same conditions.
involved in regulation of bone morphogenetic protein activities in cartilage tissues in the adult skeleton
Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (zeige SMN1 Antikörper), and COL1a1 (zeige COL1A1 Antikörper) expression in a liver fibrosis disease model.
Grem1 expression in the tubular epithelial compartment plays a significant role in the fibrotic response to renal injury in vivo.
Gremlin-1 protein expression was detected specifically in the lung after birth and did not result in any signs of respiratory insufficiency. CXCL10 chemokine le (zeige CXCL10 Antikörper)vels correlate negatively with gremlin-1 levels in mouse and human lung.
Data show that parathyroid hormone-related protein (PTHrP) regulates gremlin levels in pancreatic acinar and stellate cells.
Gremlin is a key pro-fibrogenic factor in chronic pancreatitis
Gremlin/VEGFR2 (zeige KDR Antikörper) axis participates in renal inflammation and could be a novel target for kidney disease.
GREM1 induces fibrosis and angiogenesis in mouse peritoneum and is associated with increased solute transport in peritoneal dialysis patients.
Wattles in goats are associated with the FMN1 (zeige FMN1 Antikörper)/GREM1 region on chromosome 10
COX-2 (zeige COX2 Antikörper), GREM1, and HAS2 (zeige HAS2 Antikörper) are cumulus cell genes that potentially determine oocyte and embryo developmental competence. (Review)
Platelet derived Gremlin-1 might contribute to the elevated circulating levels of Gremlin-1 in acute coronary syndromes and serve as a thrombo-inflammatory mediator in cardiovascular pathophysiologies.
gremlin protects skin cells from UV damages via activating VEGFR2 (zeige KDR Antikörper)-Nrf2 (zeige GABPA Antikörper) signaling
Gene duplication upstream of GREM1 was screened for in all sixty-five SPS (zeige SMS Antikörper) individuals with no carriers being identified.
Nox1 (zeige NOX1 Antikörper)-SHH (zeige SHH Antikörper)-Grem1 signaling axis in pulmonary vascular endothelium that is likely to contribute to Pulmonary hypertension.
GREM1 plays an important role in the development of glioma, and it may serve as a potential target in glioma therapy.
Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5 (zeige SCG5 Antikörper)-GREM1 duplication.
GREM1 is frequently expressed by myofibroblasts in scars or in the stroma of basal cell carcinomas, suggesting that GREM1 expression can be a marker for activated myofibroblasts in the cancer stroma or in scar tissue.
Clinical features of hereditary mixed polyposis syndrome caused by GREM1 gene duplication include extracolonic tumors, onset of polyps in adolescence, and rapid progression of some polyps to advanced adenomas.
both the regenerating and contralateral, developing limb of grem1 transgenics developed skeletal defects, suggesting that overexpressing grem1 negatively affects limb patterning
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
gremlin 1 homolog a, cysteine knot superfamily
, gremlin 1 homolog, cysteine knot superfamily
, gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
, gremlin 1
, cysteine knot superfamily 1
, cysteine knot superfamily 1, BMP antagonist 1
, down-regulated in Mos-transformed cells protein
, down-regulated in v-mos-transformed cells
, gremlin 1, cysteine knot superfamily, homolog
, Cysteine knot superfamily 1, BMP antagonist 1
, DAN domain family member 2
, cell proliferation-inducing gene 2 protein
, gremlin 1-like protein
, increased in high glucose-2