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Epigenetic factor EPC1 (zeige SERPINF1 Proteine) is a master regulator of DNA damage response by interacting with E2F1 (zeige E2F1 Proteine) to silence death and activate metastasis-related gene signatures
Silencing EPC1 (zeige SERPINF1 Proteine) by short hairpin RNA technology had the inhibition effects on cell proliferation and tumor growth in lung cancer
EPC1 (zeige SERPINF1 Proteine) and EPC2 are components of a complex that directly or indirectly serves to prevent MYC (zeige MYC Proteine) accumulation and AML (zeige RUNX1 Proteine) cell apoptosis, thus sustaining oncogenic potential
Epc1 (zeige SERPINF1 Proteine) plays a role in the initiation of skeletal muscle differentiation, and its interaction with Hop (zeige STIP1 Proteine) is required for the full activity.
SNP array CGH analysis of the breakpoint region in 3 ATLL-related cell lines and 4 patient samples revealed the chromosomal breakpoints are localized within the EPC1 (zeige SERPINF1 Proteine) gene locus in an ATLL-derived cell line (SO4) and in one patient with acute-type ATLL.
Results report that EPC1 and TIP60 (zeige KAT5 Proteine) are co-expressed in male germ cells. Genetic ablation of either Epc1 or Tip60 (zeige KAT5 Proteine) disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development.
results indicate that Epc1 induces vascular smooth muscle differentiation by interacting with myocardin to induce serum response factor-dependent smooth muscle genes; propose that Epc1 acts as a novel negative regulator of neointima formation after carotid injury
Epc1-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal alpha-actin (zeige ACTA1 Proteine) promoter, binding of SRF to the serum response element, and muscle-specific (zeige EIF3K Proteine) gene induction were blocked by RFP (zeige RFP Proteine).
showed that E2F6 (zeige E2F6 Proteine), DP1 (zeige REEP5 Proteine), EPC1, EZH2 (zeige EZH2 Proteine), and Sin3B (zeige SIN3B Proteine) co-elute, suggesting the identification of a novel E2F6 (zeige E2F6 Proteine) complex that exists in vivo in both normal and transformed human cell lines
Epc1 plays a role in the initiation of skeletal muscle differentiation, and its interaction with Hop (zeige STIP1 Proteine) is required for the full activity.
Epc1 is required for skeletal muscle differentiation by recruiting both SRF and p300 (zeige NOTCH1 Proteine) to the SRE of muscle-specific (zeige EIF3K Proteine) gene promoters
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants.
enhancer of polycomb homolog 1 (Drosophila)
, enhancer of polycomb 1
, enhancer of polycomb homolog 1
, enhancer of polycomb homolog 1-like
, enhancer of polycomb homolog 1 L homeolog