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PN-1 (zeige SERPINE2 Proteine) and PEDF (zeige SERPINF1 Proteine) share structural and functional features, and expression patterns in the retina.
by inhibiting the phosphorylation of VEGFR2 (zeige KDR Proteine), the P18 (zeige CDKN2C Proteine) peptide ( functional fragment of pigment epithelial-derived factor (PEDF (zeige SERPINF1 Proteine))modulates signalling transduction between VEGF (zeige VEGFA Proteine)/VEGFR2 (zeige KDR Proteine) and suppresses activation of the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) cascades, leading to an increase in mitochondrial-mediated apoptosis and anti-angiogenic activity.
Using AFM (zeige AFM Proteine) to image where exogenous hPEDF bound in rabbit femur, findings demonstrate that PEDF (zeige SERPINF1 Proteine) binds heterogeneously in cortical rabbit femur. Exogenous PEDF (zeige SERPINF1 Proteine) binding was concentrated at areas between microstructures with highly aligned collagen fibrils. Binding was not observed on or within the collagen fibrils themselves.
PEDF (zeige SERPINF1 Proteine) was acutely regulated by a glucose load and was correlated with BMI but not with diabetes.
The findings indicate that PEDF (zeige SERPINF1 Proteine) functions as a tumor-suppressor gene in the occurrence of epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma.
the T allele of rs8075977 in the 5'-flanking region of the PEDF (zeige SERPINF1 Proteine) gene may be protective for Coronary Artery Disease
PEDF (zeige SERPINF1 Proteine) exacerbates cartilage degeneration in an age-dependent manner under inflammatory conditions.
the trophoblast-derived anti-angiogenic molecule PEDF (zeige SERPINF1 Proteine) is involved in restricting growth and expansion of the feto-placental endothelium predominantly in late pregnancy and targets to modulate the intracellular effect of VEGF (zeige VEGFA Proteine)
Mutations in SERPINF1 (zeige SERPINF1 Proteine) result in osteogenesis imperfecta (zeige COL1A2 Proteine) Type VI
Expression of GLUT1 (zeige SLC2A1 Proteine) is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 (zeige SLC2A1 Proteine) in the cell membrane that contributes to the impairment of the RPE (zeige RPE Proteine) secretory function of PEDF (zeige SERPINF1 Proteine).
Results report that EPC1 and TIP60 (zeige KAT5 Proteine) are co-expressed in male germ cells. Genetic ablation of either Epc1 or Tip60 (zeige KAT5 Proteine) disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development.
results indicate that Epc1 induces vascular smooth muscle differentiation by interacting with myocardin to induce serum response factor-dependent smooth muscle genes; propose that Epc1 acts as a novel negative regulator of neointima formation after carotid injury
Epc1-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal alpha-actin (zeige ACTA1 Proteine) promoter, binding of SRF to the serum response element, and muscle-specific (zeige EIF3K Proteine) gene induction were blocked by RFP (zeige RFP Proteine).
showed that E2F6 (zeige E2F6 Proteine), DP1 (zeige REEP5 Proteine), EPC1, EZH2 (zeige EZH2 Proteine), and Sin3B (zeige SIN3B Proteine) co-elute, suggesting the identification of a novel E2F6 (zeige E2F6 Proteine) complex that exists in vivo in both normal and transformed human cell lines
Epc1 plays a role in the initiation of skeletal muscle differentiation, and its interaction with Hop (zeige STIP1 Proteine) is required for the full activity.
Epc1 is required for skeletal muscle differentiation by recruiting both SRF and p300 (zeige NOTCH1 Proteine) to the SRE of muscle-specific (zeige EIF3K Proteine) gene promoters
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants.
cell proliferation-inducing gene 35 protein
, pigment epithelium-derived factor
, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
, serpin F1
, enhancer of polycomb homolog 1 (Drosophila)
, enhancer of polycomb 1
, enhancer of polycomb homolog 1
, enhancer of polycomb homolog 1-like
, enhancer of polycomb homolog 1 L homeolog