anti-Human DMPK Antikörper für Immunofluorescence

Recommended DMPK Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Dystrophia Myotonica-Protein Kinase (DMPK) Antikörper
  • DMPK
  • DM
  • DM1
  • DM1PK
  • DMK
  • MDPK
  • MT-PK
  • Dm15
  • DM1 protein kinase
  • dystrophia myotonica-protein kinase
  • DMPK
  • Dmpk
Epitop
AA 390-500
17
9
8
8
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human
76
23
18
4
3
2
2
1
1
Wirt
Maus
69
9
Klonalität
Monoklonal
Konjugat
Dieser DMPK Antikörper ist unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
61
29
13
8
6
4
2
2
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN968595
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
11.7403755 ABIN4305449 ICC IF IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
11.7403755 ABIN4305450 ICC IF IHC IHC (p) Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Dystrophia Myotonica-Protein Kinase (DMPK) Antikörper
Epitop AA 390-500
(17), (9), (8), (8), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(76), (23), (18), (4), (3), (2), (2), (1), (1)
Wirt Maus
(69), (9)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser DMPK Antikörper ist unkonjugiert
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (IF), Western Blotting (WB)
(61), (29), (13), (8), (6), (4), (2), (2), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-DMPK Antikörper

Target Details DMPK Anwendungsinformationen Handhabung Referenzen für anti-DMPK Antikörper (ABIN968595) Bilder
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung Purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human DMPK
Klon 17
Isotyp IgG1

Target Details DMPK

Produktdetails anti-DMPK Antikörper Anwendungsinformationen Handhabung Referenzen für anti-DMPK Antikörper (ABIN968595) Bilder zurück nach oben
Antigen
Andere Bezeichnung DMPK (DMPK Antibody Abstract)
Hintergrund Myotonic dystrophy (DM), characterized by myotonia and progressive muscle weakness, results from an expanding CTG trinucleotide repeat in the 3' untranslated region of DMPK, a putative Ser/Thr kinase from the Rho-associated enzyme family. DMPK (Myotonic Dystrophy Protein Kinase) is a cytosolic protein that is found in many tissues, especially skeletal and cardiac muscle. Overexpression of DMPK in lens epithelial cells leads to apoptotic-like membrane blebbing and reorganization of the actin cytoskeleton. This effect is similar to that displayed after overexpression of RhoA in epithelial cells. The mutation of DMPK in DM yields decreased DMPK protein levels via increased nuclear retention of DMPK transcripts. Since DMPK knockout mice do not exhibit the extreme phenotype of DM patients, other factors are likely to be involved. MKBP (myotonic dystrophy protein kinase binding protein) is a small heat shock protein that specifically associates with and activates DMPK and protects it from heat-induced inactivation. Thus, DMPK association with MKBP may be important for phospho-regulation of a variety of DMPK substrates, such as cytoskeletal and membrane proteins.
Synonyms: Myotonic Dystrophy Protein Kinase
Molekulargewicht 88 kDa
Pathways Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development

Anwendungsinformationen

Produktdetails anti-DMPK Antikörper Target Details DMPK Handhabung Referenzen für anti-DMPK Antikörper (ABIN968595) Bilder zurück nach oben
Kommentare

Related Products: ABIN968533, ABIN967389

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Handhabung

Produktdetails anti-DMPK Antikörper Target Details DMPK Anwendungsinformationen Referenzen für anti-DMPK Antikörper (ABIN968595) Bilder zurück nach oben
Format Liquid
Konzentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C

Referenzen für anti-DMPK Antikörper (ABIN968595)

Produktdetails anti-DMPK Antikörper Target Details DMPK Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Jin, Shimizu, Balasubramanyam, Epstein: "Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells." in: Cell motility and the cytoskeleton, Vol. 45, Issue 2, pp. 133-48, 2000

Pham, Man, Lam, Morris: "Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies." in: Human molecular genetics, Vol. 7, Issue 12, pp. 1957-65, 1998

Mahadevan, Amemiya, Jansen, Sabourin, Baird, Neville, Wormskamp, Segers, Batzer, Lamerdin: "Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene." in: Human molecular genetics, Vol. 2, Issue 3, pp. 299-304, 1993

Bilder

Produktdetails anti-DMPK Antikörper Target Details DMPK Anwendungsinformationen Handhabung Referenzen für anti-DMPK Antikörper (ABIN968595) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Dystrophia Myotonica-Protein Kinase (DMPK) (AA 390-500) antibody (ABIN968595) Western blot analysis of DMPK on a A431 cell lysate (Human epithelial carcinoma, ATCC...
Immunofluorescence (IF) image for anti-Dystrophia Myotonica-Protein Kinase (DMPK) (AA 390-500) antibody (ABIN968595) Immunofluorescence staining of A431 cells (Human epithelial carcinoma, ATCC CRL-1555).
 image for anti-Dystrophia Myotonica-Protein Kinase (DMPK) (AA 390-500) antibody (ABIN968595) anti-Dystrophia Myotonica-Protein Kinase (DMPK) (AA 390-500) antibody (Image 3)