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Hexacosanol activates AMPK (zeige PRKAA1 Proteine) and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
increase in SREBP-2 directly activates expression of patatin-like phospholipase domain-containing enzyme 8 (PNPLA8 (zeige PNPLA8 Proteine)) gene, and PNPLA8 (zeige PNPLA8 Proteine) associates with autophagosomes and is associated with a decrease in cellular triglyceride
Reexpression of SCAP in SCAP-deficient cells restored SREBP2 protein expression and partially restored steroidogenic responses, confirming the requirement of SCAP-SREBP2 in steroidogenesis.
The deletion of Srebf-2 and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR (zeige NR1H3 Proteine) activity and SREBP-1c (zeige SREBF1 Proteine) expression.
Data, including data from studies using transgenic mice, suggest that oligodendroglial myelination requires astrocyte-derived lipids; oligodendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), an essential factor in lipid biosynthesis along with SREBP2, results in significantly retarded CNS myelination.
The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 and increased total cholesterol contents in the prostate.
SIRT1 (zeige SIRT1 Proteine) gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT (zeige AKT1 Proteine) signalling pathway, suggesting that SIRT1 (zeige SIRT1 Proteine) gene may play a protective role against osteoarthritis.
SREBP-2 is critical for survival and limb patterning during development
Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (zeige NGFR Proteine) that via p38 MAPK (zeige MAPK14 Proteine) and caspase-3 (zeige CASP3 Proteine) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (zeige NGFB Proteine) and pro-NGF (zeige NGFB Proteine).
This study reveals SHP (zeige LAMC1 Proteine) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (zeige FGF19 Proteine).
SREBP-2 regulates autophagy-related gene expression in human liver cells.
High SREBP-2 expression is associated with hypercholesterolemia.
By altering the membrane trafficking through the lysosomes, cholesterol redistributes and regulates SREBP-2.
The gene polymorphism of SREBP2 not only significantly associated with the clinical phenotypes of osteonecrosis of the femoral head but also closely related to lipid metabolism disorder.
The current investigation indicated that the rs2267439C/T polymorphism in the SREBF-2 gene increased the T2D susceptibility in an Iranian population.
CpG sites located in SREBF2 gene showed differential methylation in association with total cholesterol. The expression of the SREBF2 was inversely associated with methylation of its corresponding CpGs.
Acidic pH-responsive SREBP2 target genes were associated with reduced overall survival of cancer patients.
these clinical and experimental results reveal a novel role of SREBP-2 in the induction of a stem cell-like phenotype and prostate cancer metastasis
These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in bipolar disorder and therefore a possible role of SREBP pathway in CNS myelination processes.
dysregulation of SIRT1 (zeige SIRT1 Proteine)-AMPK (zeige PRKAA1 Proteine)-SREBP and stimulation of NLRP3 (zeige NLRP3 Proteine) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (zeige KLF13 Proteine) and SREBP-Sp1 (zeige SP1 Proteine) activation interact to regulate low density lipoprotein receptor (zeige LDLR Proteine) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2