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Reexpression of SCAP in SCAP-deficient cells restored SREBP2 protein expression and partially restored steroidogenic responses, confirming the requirement of SCAP-SREBP2 in steroidogenesis.
The deletion of Srebf-2 and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR (zeige NR1H3 Proteine) activity and SREBP-1c (zeige SREBF1 Proteine) expression.
Data, including data from studies using transgenic mice, suggest that oligodendroglial myelination requires astrocyte-derived lipids; oligodendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), an essential factor in lipid biosynthesis along with SREBP2, results in significantly retarded CNS myelination.
The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 and increased total cholesterol contents in the prostate.
SIRT1 (zeige SIRT1 Proteine) gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT (zeige AKT1 Proteine) signalling pathway, suggesting that SIRT1 (zeige SIRT1 Proteine) gene may play a protective role against osteoarthritis.
SREBP-2 is critical for survival and limb patterning during development
Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (zeige NGFR Proteine) that via p38 MAPK (zeige MAPK14 Proteine) and caspase-3 (zeige CASP3 Proteine) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (zeige NGFB Proteine) and pro-NGF (zeige NGFB Proteine).
This study reveals SHP (zeige LAMC1 Proteine) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (zeige FGF19 Proteine).
activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique
ITCH modulates SIRT6 (zeige SIRT6 Proteine) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (zeige APOE Proteine) null mice
CpG sites located in SREBF2 gene showed differential methylation in association with total cholesterol. The expression of the SREBF2 was inversely associated with methylation of its corresponding CpGs.
Acidic pH-responsive SREBP2 target genes were associated with reduced overall survival of cancer patients.
these clinical and experimental results reveal a novel role of SREBP-2 in the induction of a stem cell-like phenotype and prostate cancer metastasis
These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in bipolar disorder and therefore a possible role of SREBP pathway in CNS myelination processes.
Date indicate that sterol regulatory element-binding proteins Srebp1 (zeige SREBF1 Proteine) and Srebp2 are essential for the metabolic reprogramming of NK cells and for the attainment of elevated glycolysis and oxidative phosphorylation.
SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes.SREBP expression was associated as cardiovascular risk factor for the severity of CAD and the poor lipid control.
High expression of SREBF2 is associated with high carotid intima-media thickness.
mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR (zeige ELAVL1 Proteine) circuit, although the deficiency triggers transient pro-inflammatory signals.
Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells.
dysregulation of SIRT1 (zeige SIRT1 Proteine)-AMPK (zeige PRKAA1 Proteine)-SREBP and stimulation of NLRP3 (zeige NLRP3 Proteine) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (zeige KLF13 Proteine) and SREBP-Sp1 (zeige SP1 Proteine) activation interact to regulate low density lipoprotein receptor (zeige LDLR Proteine) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2