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BMP4-dependent expression of Xenopus Grainyhead-like 1 has a critical role in epidermal differentiation
Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein
All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT
it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1.
Grhl1 deficiency affects inner ear development in zebrafish.
GRHL1, GRHL2, and GRHL3 have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]
Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells.
A significant role for HDAC3 in the MYCN-mediated repression of GRHL1.
Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.
LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity.
Includes a comparison to TFCP2L2, the GRHL1 protein.
Grhl2 regulation of SPINT1 expression controls salivary gland development
Significant changes in blood pressure were observed in mice lacking the GRHl1 gene following high and low sodium diet.
No involvement of Grhl1 in blood pressure regulation, but Grhl1 expression influences the regulation of heart rate.
Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin.
Grainyhead like 1 is a transcriptional regulator that may perform important functions in epithelial tissues of mammals and is epidermally expressed
Grhl genes are highly expressed in the developing epidermis.
Important regulator of the desmoglein 1 genes in the context of hair anchorage and epidermal differentiation.
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development.
, grainyhead-like protein 1 homolog
, grainyhead-like-1 protein
, transcription factor CP2-like 2
, LBP protein 32
, mammalian grainyhead
, transcription factor LBP-32
, grainyhead like 1
, p61 MGR
, p70 MGR
, DNA methyltransferase 3A