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Human Polyclonal GLIPR1 Primary Antibody für ELISA - ABIN449364
Ren, Li, Yang, Timme, Goltsov, Ren, Ji, Addai, Luo, Ittmann, Thompson: RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. in Cancer research 2004
Data found that GLIPR1 expression level was low in human bladder cancer tissues. Also, GLIPR1 was shown to inhibit the expression of TPX2.
High GLIPR1 expression is associated with cisplatin resistance in lung cancer.
The present study identified GLIPR1 and miR-16 as key components for regulating the proliferation, migration, invasion and cancer-initiating cells in osteosarcoma
This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth.
Overexpression of RTVP-1 in human neural stem cells induced mesenchymal differentiation, whereas silencing of RTVP-1 in glioma stem cells (GSCs) decreased the mesenchymal transformation and stemness of these cells.
RTVP-1 regulates glioma cell spreading, migration and invasion and that these effects are mediated via interaction with N-WASP and by interfering with the inhibitory effect of hnRNPK on the function of this protein.
Data indicate that combining adenoviral vector-mediated GLIPR1 gene therap (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors.
Based on the observed overexpression in AML samples, GliPR1 should be further explored as a potential target for AML
miR-137 inhibits Glioblastom stem cell self-renewal and promotes their differentiation by targeting RTVP-1 which down-regulates CXCR4.
GLIPR1 interacts with Hsc70, and GLIPR1 overexpression or Hsc70 knockdown leads to transcriptional suppression of AURKA and TPX2.
GLIPR1 core structure has a conserved central cavity via which CAP proteins are likely to bind to shared ligands.
Data show that the expression of GLIPR1 and c-Myc were inversely correlated in prostate cancer.
RTVP-1 plays a role in the effect of serum response factor on glioma cell migration
demonstrate that GLIPR1 is a methylation-silenced gene in the acute myeloid leukemia patients
GLIPR1 expression is downregulated or even lost by promoter methylation in acute myeloid leukemia.
X-ray data have been collected to beyond 1.9 A resolution from a crystal of GLIPR1 that belonged to the orthorhombic space group P2(1)2(1)2 with average unit-cell parameters a = 85.1, b = 79.5, c = 38.9 A and either a monomer or dimer
Induction of GliPR expression by HIV-1 was confirmed in P4-CCR5 cells.
Expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels.
In this study we report the identification and characterization of a novel p53 target gene cluster that includes human RTVP1 (hRTVP-1) together with two GLIPR1L genes (GLIPR1L1 and GLIPR1L2) on human chromosome 12q21 and mouse Rtvp1
RTVP-1b is a novel splice variant of human RTVP-1, which was isolated from the U87 glioma cell line
The genetic variation is a key determining factor for the alternative splicing events in the Gli1 5' UTRs, which have functional implications on translational efficiency.
Identification of a novel mouse gene, mRTVP-1, as a p53 target gene. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 protein by two short in-frame deletions of two and nine amino acids. (mRTVP-1)
This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
GLI pathogenesis-related 1 (glioma)
, glioma pathogenesis-related protein 1
, gliPR 1
, protein RTVP-1
, related to testis-specific, vespid, and pathogenesis proteins 1
, testes-specific vespid and pathogenesis protein 1
, related to testes-specific, vespid, and pathogenesis proteins
, GLI pathogenesis-related 1
, glioma pathogenesis-related protein
, GLIPR1-like protein 1