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7 | ABIN357712 | EIA IHC (p) WB | Rabbit | Ig Fraction | Middle Region | Anmelden zum Anzeigen | Polyclonal | 2 |
General |
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Antigen | Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) Antikörper |
Epitop | N-Term Alternativen |
Reaktivität | Human, Maus Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser FDFT1 Antikörper ist unkonjugiert Alternativen |
Applikation |
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternativen
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6 Publikationen vorhanden |
Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-FDFT1 AntikörperTarget Details FDFT1 Anwendungsinformationen Handhabung Referenzen für anti-FDFT1 Antikörper (ABIN357711) Bilder |
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Spezifität | This antibody detects FDFT1 (N-term). |
Reinigung | Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human FDFT1. |
Isotyp | Ig Fraction |
Plasmids, Primers & others | |
Target Details FDFT1Produktdetails anti-FDFT1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-FDFT1 Antikörper (ABIN357711) Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | Squalene Synthetase (FDFT1 Antibody Abstract) |
Hintergrund | FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.Synonyms: FDFT1, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, SQS, SS |
Molekulargewicht | 48115 Da |
Gen-ID | 2222, 5874 |
UniProt | P37268 |
Pathways | Regulation of Lipid Metabolism by PPARalpha |
AnwendungsinformationenProduktdetails anti-FDFT1 Antikörper Target Details FDFT1 Handhabung Referenzen für anti-FDFT1 Antikörper (ABIN357711) Bilder zurück nach oben |
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Applikations-hinweise |
ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-FDFT1 Antikörper Target Details FDFT1 Anwendungsinformationen Referenzen für anti-FDFT1 Antikörper (ABIN357711) Bilder zurück nach oben |
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Format | Liquid |
Konzentration | 0.25 mg/mL |
Buffer | PBS with 0.09 % (W/V) Sodium Azide as preservative. |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freezing and thawing. |
Lagerung | 4 °C/-20 °C |
Informationen zur Lagerung | Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. |
Referenzen für anti-FDFT1 Antikörper (ABIN357711)Produktdetails anti-FDFT1 Antikörper Target Details FDFT1 Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Allgemeine Veröffentlichungen |
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 Soltis, McMahon, Caplan, Dudas, Chamberlin, Vattay, Dottavio, Rucker, Engstrom, Cornell-Kennon: "Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems." in: Archives of biochemistry and biophysics, Vol. 316, Issue 2, pp. 713-23, 1995 Summers, Karst, Charles: "Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase." in: Gene, Vol. 136, Issue 1-2Che, pp. 185-92, 1994 Jiang, McKenzie, Conrad, Shechter: "Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase." in: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12818-24, 1993 Robinson, Tsay, Kienzle, Smith-Monroy, Bishop: "Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation." in: Molecular and cellular biology, Vol. 13, Issue 5, pp. 2706-17, 1993 Zinkl, Roberts, Shea, Lasmanis: "Toxicity of acephate and methamidophos to dark-eyed juncos." in: Archives of environmental contamination and toxicology, Vol. 10, Issue 2, pp. 185-92, 1981 |
BilderProduktdetails anti-FDFT1 Antikörper Target Details FDFT1 Anwendungsinformationen Handhabung Referenzen für anti-FDFT1 Antikörper (ABIN357711) zurück nach oben |
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Bilder des Herstellers |