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commonly overexpressed COX (zeige COX8A Proteine) in cancer (~90% of colon cancer patients) can be taken advantage to suppress cell growth by knocking down delta-5-desaturase (D5D, a key enzyme that converts DGLA to arachidonic acid). In addition, D5D knockdown along with DGLA supplement may enhance the efficacy of chemotherapeutic drugs
In minor allele carriers of FADS1 and FADS2 (zeige FADS2 Proteine), plasma arachidonic acid (ARA (zeige FOXC1 Proteine)) content was elevated only at the highest level of ARA (zeige FOXC1 Proteine) consumed in infant formula. ARA (zeige FOXC1 Proteine) level in plasma is reduced by low ARA (zeige FOXC1 Proteine) consumption and by minor alleles in FADS in infants fed ARA (zeige FOXC1 Proteine)-containing formula.
D5D knockdown in conjunction with dihomo-gamma-linolenic acid treatment can also be used to inhibit growth of pancreatic cancer cells via p53 (zeige TP53 Proteine) independent pathway.
Our results showed that knockdown of delta-5-desaturase along with DGLA supplement not only significantly inhibited cell migration, but also improved the efficacies of 5-flurouracil and gemcitabine, two frontline chemotherapy drugs currently used in the treatment of colon and pancreatic cancer.
The majority of CpG sites (117 out of 136, 86%) exhibited high levels of methylation with the greatest variability observed at three key regulatory regions-the promoter regions for FADS1 and FADS2 (zeige FADS2 Proteine) and a putative enhancer site between the two genes.
FADS1 rs174547 and FADS2 (zeige FADS2 Proteine) rs2727270 genotypes were significantly correlated with decreased HDL (zeige HSD11B1 Proteine)-C concentrations, and D5D /D6D (zeige FADS2 Proteine) activities as estimated as 20:4(n-6)/20:3 (n-6) and 18:3 (n-6)/18:2 (n-6) in a linear pattern in patients with type 2 diabetes
Results indicate that genetic variation in the FADS1 gene, rs174546, influences blood pressure via arachidonic acid and body mass index. Thus, polymorphisms with an impact on the delta-5 desaturase activity may play a role for the blood pressure level mediated through polyunsaturated fatty acids and body mass index.
FADS1 rs174549 polymorphism and fish consumption may be protective factors for oral cancer, with a gene-diet multiplicative interaction
The derived allele of rs174557, which is the common variant in most populations, diminishes binding of PATZ1 (zeige ZNF278 Proteine), a transcription factor conferring allele-specific downregulation of FADS1.
This study showed associations between FADS 1/2 SNPs and cognitive performance. rs1535 minor allele homozygosity and rs174448 major allele carriage associated with improved cognitive performance in 8- to 11-y-old boys but not in girls, thereby counteracting existing sex differences.
differential PUFA profiles between HET mice and human FADS SNPs suggest low expression of both FADS1 and 2 genes in human minor haplotypes.
Data indicate that delta-5 desaturase (D5D) inhibition was confirmed by determining changes in blood arachidonic acid/dihomo-gamma-linolenic acid (AA/DGLA) profiles.
knockdown of Elovl5, Fads1, or Fads2 (zeige FADS2 Proteine) decreased the level of Mead acid.
The Systemic disruption of the Fads1 gene reciprocally altered the levels of dihomo-gamma-linolenic acid and AA in mouse tissues, resulting in a profound increase in 1-series-derived and a concurrent decrease in 2-series-derived prostaglandins.
analysis of mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle
n-3 fatty acid desaturase (zeige SCD Proteine) may have a role in colitis-associated colon cancer in mice
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1\; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.
, delta(5) fatty acid desaturase
, delta-5 desaturase
, delta-5 fatty acid desaturase
, linoleoyl-CoA desaturase (delta-6-desaturase)-like 1
, fatty acid desaturase 1