anti-Maus CLOCK Antikörper für Immunohistochemistry

Recommended CLOCK Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Clock Homolog (Mouse) (CLOCK) Antikörper
  • CG7391
  • CLK
  • CLOCK
  • Dmel\\CG7391
  • Jerk
  • Jrk
  • PAS1
  • bHLHe10
  • clk
  • clock
  • dCLK
  • dCLK/JRK
  • dCLOCK
  • dClck
  • dClk
  • dClock
  • dclk
  • jrk
  • Xclk
  • XClock
  • zCLOCK1
  • zfCLOCK1
  • 5330400M04Rik
  • KAT13D
  • bHLHe8
  • mKIAA0334
  • Clock
  • clock circadian regulator
  • clock homolog (mouse)
  • clock circadian regulator a
  • circadian locomotor output cycles kaput
  • clock circadian regulator L homeolog
  • Clk
  • CLOCK
  • clock
  • clocka
  • Clock
  • clock.L
Epitop
N-Term
19
7
7
5
5
4
4
3
2
2
1
1
1
1
1
Reaktivität
Human, Maus
106
46
32
5
5
4
4
3
3
3
3
2
2
1
1
1
Wirt
Kaninchen
67
38
13
1
Klonalität
Polyklonal
Konjugat
Dieser CLOCK Antikörper ist unkonjugiert
2
2
2
1
1
1
Applikation
Immunohistochemistry (IHC)
108
58
41
21
15
12
10
5
4
3
2
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN965906
$ 396.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
16.252611 ABIN3183967 ELISA IHC WB Rabbit IgG Internal Region Anmelden zum Anzeigen Polyclonal 0
16.12996 ABIN6260894 ELISA ICC IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
16.12996 ABIN6260895 ELISA ICC IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
10.129958 ABIN2705900 IHC WB Rabbit Center Anmelden zum Anzeigen Polyclonal 0
10.129958 ABIN1533501 IHC ELISA WB Rabbit IgG AA 241-290 Anmelden zum Anzeigen Polyclonal 1
10.129958 ABIN962571 IHC IHC (p) IP WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
10.129958 ABIN1848962 IHC ELISA WB Rabbit Internal Region Anmelden zum Anzeigen Polyclonal 0
7 ABIN2889318 ELISA IHC IHC (p) WB Rabbit IgG AA 241-290 Anmelden zum Anzeigen Polyclonal 0
7 ABIN1575729 IHC ELISA WB Rabbit Internal Region Anmelden zum Anzeigen Polyclonal 0
4 ABIN5897432 ELISA IHC WB Goat AA 458-472 Anmelden zum Anzeigen Polyclonal 0
1 ABIN6104619 ELISA IHC WB Rabbit IgG Internal Region Anmelden zum Anzeigen Polyclonal 0
1 ABIN2971465 IHC WB Rabbit Center Anmelden zum Anzeigen Polyclonal 0
1 ABIN802827 IHC ELISA WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN1856895 IHC ELISA WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN2857406 IHC WB Rabbit Anmelden zum Anzeigen Polyclonal 0
0.97973156 ABIN4299234 ICC IF IHC IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0

General

Antigen Clock Homolog (Mouse) (CLOCK) Antikörper
Epitop N-Term
(19), (7), (7), (5), (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Maus
(106), (46), (32), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Wirt Kaninchen
(67), (38), (13), (1)
Klonalität
Polyklonal
Konjugat Dieser CLOCK Antikörper ist unkonjugiert
(2), (2), (2), (1), (1), (1)
Applikation Immunohistochemistry (IHC)
(108), (58), (41), (21), (15), (12), (10), (5), (4), (3), (2), (2)
Pubmed 9 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CLOCK Antikörper

Target Details CLOCK Anwendungsinformationen Handhabung Referenzen für anti-CLOCK Antikörper (ABIN965906) Bilder
Reinigung Purified by antigen-specific affinity chromatography.
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human CLOCK(Circadian locomoter output cycles protein kaput)
Plasmids, Primers & others

Target Details CLOCK

Produktdetails anti-CLOCK Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CLOCK Antikörper (ABIN965906) Bilder zurück nach oben
Antigen
Andere Bezeichnung CLOCK (CLOCK Antibody Abstract)
Hintergrund CLOCK(Circadian locomoter output cycles protein kaput) is a circadian regulator that acts as a transcription factor. CLOCK-BMAL1 heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Mutant CLOCK and BMAL1 form hetereodimers that bind DNA, but fail to activate transcription. CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
Pathways Regulation of Lipid Metabolism by PPARalpha, Photoperiodism

Anwendungsinformationen

Produktdetails anti-CLOCK Antikörper Target Details CLOCK Handhabung Referenzen für anti-CLOCK Antikörper (ABIN965906) Bilder zurück nach oben
Applikations-hinweise ELISA, Western blotting: 1µg/ml for 2hrs.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CLOCK Antikörper Target Details CLOCK Anwendungsinformationen Referenzen für anti-CLOCK Antikörper (ABIN965906) Bilder zurück nach oben
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C

Referenzen für anti-CLOCK Antikörper (ABIN965906)

Produktdetails anti-CLOCK Antikörper Target Details CLOCK Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Sato, Yamada, Ukai, Baggs, Miraglia, Kobayashi, Welsh, Kay, Ueda, Hogenesch: "Feedback repression is required for mammalian circadian clock function." in: Nature genetics, Vol. 38, Issue 3, pp. 312-9, 2006

Shirogane, Jin, Ang, Harper: "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein." in: The Journal of biological chemistry, Vol. 280, Issue 29, pp. 26863-72, 2005

Pirovano, Lorenzi, Serretti, Ploia, Landoni, Catalano, Smeraldi: "Two new rare variants in the circadian "clock" gene may influence sleep pattern." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 7, Issue 6, pp. 455-7, 2005

Miyazaki, Nagase, Mesaki, Narukawa, Ohara, Ishida: "Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts." in: The Biochemical journal, Vol. 380, Issue Pt 1, pp. 95-103, 2004

Lee, Weaver, Reppert: "Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 584-94, 2003

Kondratov, Chernov, Kondratova, Gorbacheva, Gudkov, Antoch: "BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system." in: Genes & development, Vol. 17, Issue 15, pp. 1921-32, 2003

Steeves, King, Zhao, Sangoram, Du, Bowcock, Moore, Takahashi: "Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei." in: Genomics, Vol. 57, Issue 2, pp. 189-200, 1999

Jin, Shearman, Weaver, Zylka, de Vries, Reppert: "A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock." in: Cell, Vol. 96, Issue 1, pp. 57-68, 1999

Produkt verwendet in:

Moreira, Pedrazzoli, Dos Santos Coelho, Pradella-Hallinan, Lopes da Conceição, Pereira Peregrino, de Oliveira, Tufik: "Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients." in: Brain research. Molecular brain research, Vol. 140, Issue 1-2, pp. 150-4, 2005