anti-ANGPTL4 (ANGPTL4) Antikörper

Human Angiopoietin-Like 4 (ANGPTL4) Interaktionspartner

1. Levels of ANGPTL4 in the circulation and HDLs (zeige CSF1R Antikörper) were increased in type 2 diabetics altering lipid metabolism.

2. High expression of ANGPTL4 is associated with drug resistance in prostate cancer.

3. circulating ANGPTL3 (zeige ANGPTL3 Antikörper) and ANGPTL 4 expression was significantly elevated in hepatocellular carcinoma cases compared to chronic hepatitis patients and controls

4. this study suggests that the presence of C allele of rs1044250 and G allele of rs2278236 in ANGPTL4 gene is associated with higher risk of moderate/severe proteinuria in renal transplant patients

5. These results suggested that ANGPTL4 was essential for proliferation and metastasis of lung cancer cells.

6. The mutant tumors exhibited impaired proliferation, anoikis resistance, and migratory capability and had reduced adenylate energy charge. Further investigations also revealed that cANGPTL4 regulated the expression of Glut2 (zeige SLC2A2 Antikörper)

7. Data indicate angiopoietin-like 4 (ANGPTL4) as a key player that coordinates an increase in cellular energy flux crucial for EMT (zeige ITK Antikörper) via an ANGPTL4/14-3-3gamma (zeige YWHAG Antikörper) signaling axis.

8. The authors now show: (1) that ANGPTL4 inactivates LPL (zeige LCP1 Antikörper) by catalyzing the unfolding of its hydrolase domain; (2) that binding to GPIHBP1 (zeige GPIHBP1 Antikörper) renders LPL (zeige LCP1 Antikörper) largely refractory to this inhibition; and (3) that both the LU domain and the intrinsically disordered acidic domain of GPIHBP1 (zeige GPIHBP1 Antikörper) are required for this protective effect.

9. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene.

10. reduced expression of one of the survival-associated transcripts, Angiopoietin-like 4, impairs growth of a gemcitabine-resistant pancreatic cancer cell line.

Cow (Bovine) Angiopoietin-Like 4 (ANGPTL4) Interaktionspartner

1. increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow

2. These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion.

Mouse (Murine) Angiopoietin-Like 4 (ANGPTL4) Interaktionspartner

1. The influence of H2O2 on ANGPTL4 provided new insight into the mechanism of atherosclerosis.

2. The reduction of plasma triglyceride levels in Angptl4(-/-) mice and increase following Angptl4 overexpression suggest that changes in plasma triglyceride metabolism do not regulate alpha-cells in the pancreas. Our findings corroborate recent data showing that increased plasma amino acids and their transport into alpha-cells link glucagon receptor (zeige GCGR Antikörper) blockage to alpha-cell hyperplasia

3. study demonstrates the key role of Angptl4 in glucocorticoid-augmented hepatic ceramide production that induces whole-body insulin (zeige INS Antikörper) resistance.

4. 1) ANGPTL4 is not involved in the triglyceride-lowering effect ofbile acids ; 2) ANGPTL4 promotes bile acids absorption during taurocholic acid supplementation via a mechanism dependent on the gut (zeige GUSB Antikörper) microbiota.

5. physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL (zeige LPL Antikörper) in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL (zeige LPL Antikörper) by stimulating LPL (zeige LPL Antikörper) degradation after LPL (zeige LPL Antikörper) processing in the endoplasmic reticulum (ER).

6. This study shows that TNF-alpha (zeige TNF Antikörper), by a Foxo1 (zeige FOXO1 Antikörper) dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL (zeige LPL Antikörper).

7. Angptl4-deficient mice show impaired insulin (zeige INS Antikörper) secretion and dysmorphic pancreatic islets.

8. Angptl4 induces obesity-associated metabolic disorders. The present study suggested that Angptl4 promotes liver steatosis and lipolysis, in addition to impairing liver function; while Angptl4 improves glucose tolerance and insulin (zeige INS Antikörper) resistance, in addition to causing the downregulation of various insulin (zeige INS Antikörper) signaling pathway-associated genes.

9. ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to brown adipose tissue during cold.

10. This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 (zeige ANGPTL3 Antikörper) and Angptl4 at different nutritional statuses.

Pig (Porcine) Angiopoietin-Like 4 (ANGPTL4) Interaktionspartner

1. The ANGPTL4 G/A polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) showed a significant effect on intramuscular fat

Zebrafish Angiopoietin-Like 4 (ANGPTL4) Interaktionspartner

1. These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer.