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study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases
The interaction between XCL1 and XCR1 (zeige XCR1 Proteine) plays a crucial role in the classical immunology response.
Data show that mice lacking either XCL1 or XCR1 (zeige XCR1 Proteine) exhibit similar specific defects in intestinal T cell populations as XCR1 (zeige XCR1 Proteine)-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1 (zeige XCR1 Proteine)-XCL1 axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1 (zeige XCR1 Proteine)+ DCs or be independent of this pathway.
T inflammatory memory CD8 (zeige CD8A Proteine) T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production
XCL1-mediated accumulation of dendritic cells in the thymic medulla contributes to naturally occurring regulatory T cell development and is regulated by Aire (zeige AIRE Proteine).
Data report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells.
The expression patterns of XCR1 (zeige XCR1 Proteine) and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets.
MIP-1alpha (zeige CCL3 Proteine), MIP-1beta (zeige CCL4 Proteine), RANTES (zeige CCL5 Proteine), and ATAC/lymphotactin function together with IFN-gamma (zeige IFNG Proteine) as type 1 cytokines.
Adenovirus-mediated intratumoral Lptn gene transfer potentiates the antibody-targeted superantigen therapy of experimental melanoma.
In a brain-targeted HIV-1 Tat transgenic model, Tat exp (zeige TAT Proteine)ression up-regulates XCL1 production not only in Tat-expressing murine astrocytes, but also in monocytes and macrophages/microglia.
higher serum XCL1 levels at diagnosis and their progressive decline throughout chemotherapy could be correlated with higher survival.
This study defines a Glycosaminoglycan binding surface on XCL1 dimer that includes residues that are important for HIV-1 inhibition.
Electrostatics and Hydrophobic Effects in the Metamorphic Protein Human Lymphotactin
XCL1 acts via direct interaction with the external viral envelope glycoprotein (zeige ERVW-1 Proteine), gp120 (zeige ITIH4 Proteine), to block HIV-1 infection
analysis of XCL1 and XCL2 (zeige XCL2 Proteine), members of the C-chemokine (zeige CCL1 Proteine) subfamily, in the immune system
identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3 (zeige CCL3 Proteine), CCL4/CCL4L1 (zeige CCL4 Proteine)/CCL4L2, CD160 (zeige CD160 Proteine), IFNG (zeige IFNG Proteine), NR4A3 (zeige NR4A3 Proteine) and XCL1/XCL2 (zeige XCL2 Proteine)) were analyzed in 127 kidney biopsies
XCL1 displays antimicrobial activity against E. coli and S. aureus.
XCL1-mediated inhibition is associated with direct interaction of the chemokine (zeige CCL1 Proteine) with the HIV-1 envelope.
In native annulus fibrosus tissue homeostasis and repair, CXCR3 (zeige CXCR3 Proteine) is evident, whereas XCL1 could not be detected.
The distribution characters of cattle XCR1 (zeige XCR1 Proteine) and XCL1 suggested a vital role in regulation of acquired immune responses and indicated a potential for a DC targeted veterinary vaccine in cattle using XCL1 fused antigens.
This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.
chemokine (C motif) ligand 1
, c motif chemokine 1
, cytokine SCM-1
, small inducible cytokine subfamily C, member 1 (lymphotactin)
, small-inducible cytokine C1
, XC chemokine ligand 1
, single cysteine motif 1a