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Human TNFSF13 Protein expressed in HEK-293 Cells - ABIN1344412
Litinskiy, Nardelli, Hilbert, He, Schaffer, Casali, Cerutti: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. in Nature immunology 2002
Show all 9 Pubmed References
Human TNFSF13 Protein expressed in HEK-293 Cells - ABIN1344410
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. in PLoS ONE 2012
Human TNFSF13 Protein expressed in Wheat germ - ABIN1323221
Chihara, Aranami, Sato, Miyazaki, Miyake, Okamoto, Ogawa, Toda, Yamamura: Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. in Proceedings of the National Academy of Sciences of the United States of America 2011
APRIL but not BLyS (zeige TNFSF13B Proteine) promotes IL-10 (zeige IL10 Proteine) production by CpG-activated B cells and enhances the regulatory role of B cells on T cells.
BCMA (zeige TNFRSF17 Proteine) has other contributors for ligands binding except DxL motif. The affinity of BCMA (zeige TNFRSF17 Proteine) for APRIL higher than for BAFF (zeige TNFSF13B Proteine) may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
ApoE-/-APRIL-Tg mice have increased oxLDL-specific serum IgM levels, potentially mediated via an increase in B1a lymphocytes
Results showed that chemokine (zeige CCL1 Proteine)-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression.
This study showed that both BAFF (zeige TNFSF13B Proteine) and APRIL levels were increased in CSF (zeige CSF2 Proteine) of patients with anti-NMDAR (zeige GRIN1 Proteine) encephalitis.
New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA (zeige TNFRSF17 Proteine) and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM.
Urinary APRIL (uAPRIL) and BAFF (zeige TNFSF13B Proteine) (uBAFF) levels were raised significantly in AN.
Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.
Recombinant human APRIL (rhAPRIL) could rescue HCC (zeige FAM126A Proteine) cell proliferation inhibited by miR (zeige MLXIP Proteine)-383.
Host-derived proteins pp32 and APRIL interact with a free form of influenza virus RNA-dependent RNA polymerase and preferentially upregulates viral RNA synthesis rather than cRNA synthesis.
p40, a Lactobacillus rhamnosus-derived protein upregulates EGFR-dependent APRIL expression in intestinal epithelial cells, which may contribute to promoting IgA production
this study identifies APRIL as a new target involved in B-cell activation (zeige BLNK Proteine), in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice
this is the first study to implicate the APRIL signal transduction pathway in the pathogenesis of nephrogenic IgA production. Moreover, our findings identify APRIL as a potential target of therapy.
the elevated presence of APRIL and BLyS (zeige TNFSF13B Proteine) in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL (zeige TNFSF11 Proteine)-expressing B cells/plasma cells.
B cell activating factor (BAFF (zeige TNFSF13B Proteine)) and a proliferation inducing ligand (APRIL) mediate CD40 (zeige CD40 Proteine)-independent help by memory CD4 (zeige CD4 Proteine) T cells in transplantations.
Heteromers consisting of one BAFF (zeige TNFSF13B Proteine) and two APRIL bind to receptor TACI (zeige TNFRSF13B Proteine), BCMA (zeige TNFRSF17 Proteine) but not to BAFFR (zeige TNFRSF13C Proteine).
Immunization of mice with a DNA vaccine encoding BAFF (zeige TNFSF13B Proteine) or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env (zeige ERVW-1 Proteine) gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses.
APRIL selectively enhances axonal growth by activating ERK signaling and PI3-kinase/Akt/GSK-3beta signaling.
Data indicate that APRIL expression accelerates the onset of TCL1 (zeige TCL1A Proteine)-driven leukemia formation mainly through TACI (zeige TNFRSF13B Proteine) activation.
The ability of TACI (zeige TNFRSF13B Proteine)-Fc to activate reverse signalling through BAFF (zeige TNFSF13B Proteine) and APRIL, was investigated.
Although proliferation-inducing ligand TNFSF13/APRIL expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (zeige GUSB Proteine)-associated lymphoid tissue.
Cloning and expression analysis of a proliferation-inducing ligand (APRIL) provides the basis for investigation of its role in regulating rabbit B-lymphocyte (zeige AKAP17A Proteine) development and immune responses.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
TNF- and APOL-related leukocyte expressed ligand 2
, a proliferation-inducing ligand
, tumor necrosis factor ligand superfamily member 13
, tumor necrosis factor-like protein ZTNF2
, tumor necrosis factor-related death ligand-1
, SLAN protein
, Acidic leucine-rich nuclear phosphoprotein 32 family member B
, TNF superfamily member 13
, A proliferation-inducing ligand
, tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein
, tumor necrosis factor (ligand) superfamily, member 13
, tumor necrosis factor superfamily member 13
, proliferation-inducing ligand
, tumor necrosis factor ligand 7B