anti-Human TAP2 Antikörper für Enzyme Immunoassay

Recommended TAP2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2) Antikörper
  • ABC18
  • ABCB3
  • APT2
  • D6S217E
  • PSF-2
  • PSF2
  • RING11
  • AI462429
  • Abcb3
  • Ham-2
  • Ham2
  • MTP2
  • Tap-2
  • Y1
  • jas
  • Cim
  • transporter 2, ATP binding cassette subfamily B member
  • transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
  • TAP2
  • Tap2
Epitop
AA 689-703
20
5
3
2
2
2
1
1
1
1
1
1
Reaktivität
Human
87
42
41
Wirt
Kaninchen
83
3
2
Klonalität
Polyklonal
Konjugat
Dieser TAP2 Antikörper ist unkonjugiert
5
5
5
3
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
40
35
26
26
17
15
6
4
3
1
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN5551666
$ 506.00
Zzgl. Versandkosten $45.00

General

Antigen Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2) Antikörper
Epitop AA 689-703
(20), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(87), (42), (41)
Wirt Kaninchen
(83), (3), (2)
Klonalität
Polyklonal
Konjugat Dieser TAP2 Antikörper ist unkonjugiert
(5), (5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(40), (35), (26), (26), (17), (15), (6), (4), (3), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TAP2 Antikörper

Target Details TAP2 Anwendungsinformationen Handhabung Bilder
Spezifität This antibody reacts to Atp-Binding Cassette, Subfamily B (Mdr/Tap), Member 3 (Abcb3) (TAP2).
Reinigung Affinity Purified
Immunogen Synthetic peptide - KLH conjugated
Isotyp IgG

Target Details TAP2

Produktdetails anti-TAP2 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung ABCB3 / APT2 / TAP2 (TAP2 Antibody Abstract)
Hintergrund TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. TAP is also inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP is down-regulated by human Epstein-barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren's syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction.Synonyms: ATP-binding cassette sub-family B member 3, Antigen peptide transporter 2, PSF2, Peptide supply factor 2, Peptide transporter PSF2, Peptide transporter involved in antigen processing 2, RING11, Y1
Gen-ID 6891
NCBI Accession NP_000535
UniProt Q03519
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process

Anwendungsinformationen

Produktdetails anti-TAP2 Antikörper Target Details TAP2 Handhabung Bilder zurück nach oben
Applikationshinweise Immunohistochemistry on paraffin sections: 10 μg/mL. ELISA: 1/0 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TAP2 Antikörper Target Details TAP2 Anwendungsinformationen Bilder zurück nach oben
Buffer PBS containing 0.09 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.