anti-Ratte (Rattus) SH2 Domain Containing 1A Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended SH2 Domain Containing 1A Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
SH2 Domain Containing 1A (SH2D1A) Antikörper
  • DSHP
  • EBVS
  • IMD5
  • LYP
  • MTCP1
  • SAP
  • SAP/SH2D1A
  • XLP
  • XLPD
  • RGD1562408
  • Gm686
  • SH2D1A
  • SH2 domain containing 1A
  • SH2D1A
  • Sh2d1a
Reaktivität
Human, Maus, Ratte (Rattus)
114
37
32
7
7
5
2
2
1
1
1
Wirt
Kaninchen
71
33
14
1
Klonalität
Polyklonal
Konjugat
HRP
7
7
5
5
5
5
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
101
61
13
10
4
4
3
2
1
Optionen
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Hersteller Produkt- Nr.
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Produktnummer ABIN1423036
$ 405.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2888126 IF IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1405165 IHC (p) WB Biotin Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1387212 IF (p) IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen SH2 Domain Containing 1A (SH2D1A) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(114), (37), (32), (7), (7), (5), (2), (2), (1), (1), (1)
Wirt Kaninchen
(71), (33), (14), (1)
Klonalität
Polyklonal
Konjugat HRP
(7), (7), (5), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(101), (61), (13), (10), (4), (4), (3), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human SH2D1A/SAP
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung SH2D1A (SH2D1A Antibody Abstract)
Hintergrund

SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96 % homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).

Synonyms: SH2 domain protein 1A, DSHP, Duncan disease SH2 protein, SAP, Signaling lymphocyte activation molecule associated protein, SLAM associated protein, T cell signal transduction molecule SAP, SH21A_HUMAN.

Gen-ID 4068
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

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Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Konservierungsmittel Gentamicin sulfate
Vorsichtsmaßnahmen This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months