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PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes.
Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 (zeige PVR Proteine) deficiency in immune surveillance against methylcholanthrene-induced tumors.
We showed that cadherin and nectin (zeige PVRL1 Proteine) in the junctions of A431 cells and human keratinocytes are located in separate clusters.
nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis
Our functional analyses indicate that the infertility phenotype of nectin-2-deficient male mice is caused by a combination of reduced migration to the oviduct, spermatozoa-zona binding, and sperm-oocyte fusion
nectins and afadin are involved in dynamic epithelial remodeling during mouse development
Nectin-2 expression in Sertoli cells is believed via cross-talking between CREB (zeige CREB1 Proteine), c-Jun (zeige JUN Proteine), and Sp1 (zeige SP1 Proteine) family protein.
Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed.
Nectin-2 is required to maintain structure and function of the intercalated disc and protects the heart from pressure-overload-induced cardiac dysfunction.
In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin (zeige PVRL1 Proteine)-2Ig.
Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 by TIGIT (zeige TIGIT Proteine).
Chromosomal breakpoints involved the PVRR2 gene in 19q31 is associated with Diffuse Large B-Cell Lymphomas.
energetic basis for the TIGIT (zeige TIGIT Proteine)/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated.
Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients.
Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection.
PVRL2, TOMM40 (zeige TOMM40 Proteine) and APOE (zeige APOE Proteine) might be associated with human longevity.
Nectin-3 (zeige PVRL3 Proteine) trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation.
Chorionic gonadotropin induces vascular endothelial growth factor (zeige VEGF Proteine) (VEGFA (zeige VEGFA Proteine))-dependent downregulation of nectin 2, which increases the endothelial permeability in the coculture system.
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
poliovirus receptor-related protein 2
, herpes virus entry mediator B
, herpesvirus entry mediator B
, murine herpes virus entry protein B
, murine herpesvirus entry protein B
, poliovirus receptor homolog
, poliovirus sensitivity
, poliovirus receptor related 2
, poliovirus receptor-related 2 (herpesvirus entry mediator B)
, herpesvirus entry protein B
, poliovirus receptor-like 2