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Human Poliovirus Receptor Protein expressed in Human Cells - ABIN2002083
Mendelsohn, Wimmer, Racaniello: Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. in Cell 1989
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Human Poliovirus Receptor Protein expressed in HEK-293 Cells - ABIN2180698
Chandramohan, Bryant, Piao, Keir, Lipp, Lefaivre, Perkinson, Bigner, Gromeier, McLendon: Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas. in Archives of pathology & laboratory medicine 2017
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Study investigated the more detailed mechanism for this cis (zeige CISH Proteine)-interaction of Necl-5 with the PDGF (zeige PDGFA Proteine) receptor beta. Necl-5 contains three Ig-like domains and the PDGF (zeige PDGFA Proteine) receptor beta contains five Ig-like domains at their extracellular regions; showed that the third Ig-like domain of Necl-5 cis (zeige CISH Proteine)-interacted with the fifth Ig-like domain of the PDGF (zeige PDGFA Proteine) receptor beta.
Studied association of poliovirus receptor (PVR/CD155) mutation and cleft lip and cleft palate. Validated previous findings that PVR/CD155 markers are associated with cleft lip and palate.
The authors demonstrate that HIV and specifically Nef and/or Vpu do not modulate CD155 on infected primary T cells and both CD155 and NKG2D (zeige KLRK1 Proteine) ligands synergize as a natural killer cell receptor to trigger natural killer cell lysis of the infected cell.
Data show that gastric cancer cells inhibit T-cell metabolism through CD155/TIGIT (zeige TIGIT Proteine) signaling.
Studies showed that CD155 was frequently overexpressed in human malignant tumors. Its overexpression promotes tumor cell invasion and migration, and is associated with tumor progression. [review]
soluble CD226 (zeige CD226 Proteine) elevated in sera of CTCL (zeige TSPYL2 Proteine) patients would be important for tumor immunity by interacting with CD155 on tumor cells.
data reveal that MICA (zeige MICA Proteine) and PVR are directly regulated by human cytomegalovirus immediate early (zeige JUN Proteine) proteins, and this may be crucial for the onset of an early host antiviral response
The SNP detection assay was successfully developed for identification of Ala67Thr polymorphism in human PVR/CD155 gene. The SNP assay will be useful for large scale screening of DNA samples.
implying that TIGIT (zeige TIGIT Proteine) exerts immunosuppressive effects by competing with DNAM-1 (zeige CD226 Proteine) for the same ligand, CD155
The present study provides evidence that regulation of the PVR/CD155 DNAM-1 (zeige CD226 Proteine) ligand expression by nitric oxide may represent an additional immune-mediated mechanism and supports the anti-myeloma activity of nitric oxide donors.
Data show that CD155 protein/CD226 antigen (zeige CD226 Proteine) mainly mediates the interaction between NK cells and leukemic cells in acute myeloid leukemia (zeige BCL11A Proteine). To investigate the interaction between leukemic cells
absence of either CD155 or CD226 (zeige CD226 Proteine) in BALB/c mice causes a profound shift in the Natural Killer T-Cells subtype composition in thymus, expanding the frequency and numbers of iNKT1 cells at the expense of iNKT2 cells, as well as iNKT17 cells.
Results suggest that modulation of the expression of receptors and CD112 (zeige PVRL2 Proteine) compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors.
CD155 (PVR/Necl5) mediates a costimulatory signal in CD4 (zeige CD4 Proteine)+ T cells and regulates allergic inflammation.
Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR (zeige PVRL2 Proteine)-CEACAM2-L (zeige CEACAM2 Proteine) interaction in mouse testis
TIGIT (zeige TIGIT Proteine)/PVR (zeige PVRL2 Proteine) ligation signaling mediates suppression of IFN-gamma (zeige IFNG Proteine) production via the NF-kappaB (zeige NFKB1 Proteine) pathway.
Our data suggest that CD155 regulates T(h)2 differentiation
These observations establish a firm link between the functions of CD155 and CD226 (zeige CD226 Proteine) in several T cell differentiation steps.
Necl-5/poliovirus receptor interacts with VEGFR2 (zeige KDR Proteine) and regulates VEGF (zeige VEGFA Proteine)-induced angiogenesis.
The TLR3 (zeige TLR3 Proteine)-TRIF (zeige RNF138 Proteine) mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
, nectin-like 5
, nectin-like protein 5
, tumor-associated antigen 1
, tumor-associated glycoprotein pE4