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Studies showed that CD155 was frequently overexpressed in human malignant tumors. Its overexpression promotes tumor cell invasion and migration, and is associated with tumor progression. [review]
soluble CD226 (zeige CD226 ELISA Kits) elevated in sera of CTCL (zeige TSPYL2 ELISA Kits) patients would be important for tumor immunity by interacting with CD155 on tumor cells.
data reveal that MICA (zeige MICA ELISA Kits) and PVR are directly regulated by human cytomegalovirus immediate early (zeige JUN ELISA Kits) proteins, and this may be crucial for the onset of an early host antiviral response
The SNP detection assay was successfully developed for identification of Ala67Thr polymorphism in human PVR/CD155 gene. The SNP assay will be useful for large scale screening of DNA samples.
implying that TIGIT (zeige TIGIT ELISA Kits) exerts immunosuppressive effects by competing with DNAM-1 (zeige CD226 ELISA Kits) for the same ligand, CD155
The present study provides evidence that regulation of the PVR/CD155 DNAM-1 (zeige CD226 ELISA Kits) ligand expression by nitric oxide may represent an additional immune-mediated mechanism and supports the anti-myeloma activity of nitric oxide donors.
Our findings suggest that loss of CD155 expression may play an important role in the immune escape of HCC (zeige FAM126A ELISA Kits) cells and thus CD155 may serve as a prognostic marker as well as a potential therapeutic target for HCC (zeige FAM126A ELISA Kits).
CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy.
CD155 (PVR/Necl5) mediates a costimulatory signal in CD4 (zeige CD4 ELISA Kits)+ T cells and regulates allergic inflammation.
The cell-surface receptor (Pvr) catalyzes a large structural change in the poliovirus that exposes membrane-binding protein chains.
Data show that CD155 protein/CD226 antigen (zeige CD226 ELISA Kits) mainly mediates the interaction between NK cells and leukemic cells in acute myeloid leukemia (zeige BCL11A ELISA Kits). To investigate the interaction between leukemic cells
absence of either CD155 or CD226 (zeige CD226 ELISA Kits) in BALB/c mice causes a profound shift in the Natural Killer T-Cells subtype composition in thymus, expanding the frequency and numbers of iNKT1 cells at the expense of iNKT2 cells, as well as iNKT17 cells.
Results suggest that modulation of the expression of receptors and CD112 (zeige PVRL2 ELISA Kits) compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors.
Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR-CEACAM2-L interaction in mouse testis
TIGIT (zeige TIGIT ELISA Kits)/PVR (zeige PVRL2 ELISA Kits) ligation signaling mediates suppression of IFN-gamma (zeige IFNG ELISA Kits) production via the NF-kappaB (zeige NFKB1 ELISA Kits) pathway.
Our data suggest that CD155 regulates T(h)2 differentiation
These observations establish a firm link between the functions of CD155 and CD226 (zeige CD226 ELISA Kits) in several T cell differentiation steps.
Necl-5/poliovirus receptor interacts with VEGFR2 (zeige KDR ELISA Kits) and regulates VEGF (zeige VEGFA ELISA Kits)-induced angiogenesis.
The TLR3 (zeige TLR3 ELISA Kits)-TRIF (zeige RNF138 ELISA Kits) mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
, nectin-like 5
, nectin-like protein 5
, tumor-associated antigen 1
, tumor-associated glycoprotein pE4