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Human mucosal-associated invariant T cells possess capacity for B cell help via MR1-mediated immunoglobulins production.
Early endosomal TLR9 (zeige TLR9 ELISA Kits) activation is important for MR1-mediated bacterial antigen presentation in B cells.
Polymorphism in MR1 gene is associated with susceptibility to tuberculosis.
we have shown that MR1-mediated MAIT cell activation is tightly regulated at several levels. Efficient MR1-mediated MAIT cell activation requires both intact bacteria to access an acidified endolysomal compartment and activation of the APC (zeige APC ELISA Kits) through NF-kappaB (zeige NFKB1 ELISA Kits) or interferon (zeige IFNA ELISA Kits) signaling pathways.
results suggest that high expression of MR-1 is involved in hepatocellular carcinoma progression
Data show that the major histocompatibility complex, class I-related protein (MR1) antigen presentation is characterized by a rapid 'off-on-off' mechanism that is strictly dependent on antigen availability.
endosome-mediated trafficking of MR1 allows for selective sampling of the intracellular environment
Studies indicate that the antigen-presenting molecules CD1 (zeige CD1A ELISA Kits) and MHC class I-related protein (MR1) display lipids and small molecules to T cells.
Data indicate that high expression of CD26 (zeige DPP4 ELISA Kits) ia a specific markers to define major histocompatibility complex, class I-like sequence protein MR1-restricted mucosa-associated invariant T (MAIT) cells.
Mucosal-associated invariant T cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes.
MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells.
differential contribution of particular amino acids to the MAIT TCR-MR1 interaction based upon the presence of bacteria
Data suggest that constitutive expression of MR1 may be detrimental for maintenance of immune homeostasis in the gut (zeige GUSB ELISA Kits) and/or detection of pathogenic bacteria in mucosal tissues.
fact that MR1 seems mainly intracellular might offer clues as to the process, given the precedence in other class I molecules
Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice.
MR1 protein can associate with beta(2)-microglobulin (zeige B2M ELISA Kits)
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Analysis of murine MR1 expressed in a murine cell line reveals that MR1 associates with the peptide-loading complex, indicating that MR1 uses the same cellular assembly machinery as do classical class I molecules.
MR1 has an antigen presentation function
HA peptides are expressed by EGCs and recognized by CD8 T cells that express a T-cell receptor (TCR) specific for Kd:HA512-520 (CL4) or CD4 T cells that express a TCR specific for IEd:HA107-119 (6.5), respectively.
non-MHC-linked class I-related gene
MHC Rfp-Y class I alpha chain
, MHC class I-related protein
, major histocompatibility complex class I-related gene protein
, major histocompatibility complex class I-related protein variant 550
, major histocompatibility complex, class I-related
, Major histocompatibility complex class I-related gene protein
, MHC class I-like antigen MR-1
, MHC class I-related gene protein
, MHC class-I related-gene protein
, class I histocompatibility antigen-like protein
, major histocompatibility complex, class I-like sequence
, MCH class I
, histocompatibility-2 complex class 1-like sequence
, MHC class I-like sequence
, MHC class I related protein, MR1B1 isoform