anti-Maus IL12RB1 Antikörper für Flow Cytometry

Recommended IL12RB1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interleukin 12 Receptor beta 1 (IL12RB1) Antikörper
  • Il12rb
  • IL12RB1
  • IL-12R
  • CD212
  • IL-12R-BETA1
  • IL12RB
  • IL-12R[b]
  • interleukin 12 receptor subunit beta 1
  • interleukin 12 receptor, beta 1
  • Il12rb1
  • IL12RB1
Reaktivität
Maus
119
30
23
1
Wirt
Maus
79
41
22
1
Klonalität
Monoklonal
Konjugat
Dieser IL12RB1 Antikörper ist konjugiert mit Biotin
10
8
7
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
71
50
34
20
13
8
7
6
4
3
3
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Produktnummer ABIN2689093
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
9.362221 ABIN4897371 FACS PE Goat IgG AA 32-561 Anmelden zum Anzeigen Polyclonal 0
9.362221 ABIN4897369 FACS Fluorescein Goat IgG AA 32-561 Anmelden zum Anzeigen Polyclonal 0
1 ABIN596137 FACS CF Goat IgG Extracellular Domain Anmelden zum Anzeigen Polyclonal 0
1 ABIN596138 FACS PE Goat IgG Extracellular Domain Anmelden zum Anzeigen Polyclonal 0
1 ABIN2287660 FACS PE Goat IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2287658 FACS Carboxyfluorescein (CFS) Goat IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interleukin 12 Receptor beta 1 (IL12RB1) Antikörper
Reaktivität Maus
(119), (30), (23), (1)
Wirt Maus
(79), (41), (22), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IL12RB1 Antikörper ist konjugiert mit Biotin
(10), (8), (7), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Flow Cytometry (FACS)
(71), (50), (34), (20), (13), (8), (7), (6), (4), (3), (3), (2), (1), (1), (1)
Pubmed 8 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IL12RB1 Antikörper

Target Details IL12RB1 Anwendungsinformationen Handhabung Referenzen für anti-IL12RB1 Antikörper (ABIN2689093) Bilder
Marke BD Pharmingen™
Produktmerkmale The 114 antibody reacts with mouse CD212 (the β1 subunit of IL-12Rβ1), originally termed IL-12Rβ, of the mouse IL-12 receptor complex. The IL-12Rβ1 subunit associates with a β2 subunit to form a heterodimeric IL-12 receptor complex. Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity. The IL-12Rβ1 subunit interacts primarily with IL-12 p40 whereas the IL-12Rβ2 binds both to IL-12 p40 and IL-12 p35. IL-12Rβ1 is required for high affinity binding of IL-12 but IL-12Rβ2 is required for signaling. IL-12Rβ1 has more recently been described to bind IL-23, a heterodimer formed of the p40 subunit from IL-12, and p19. The cytoplasmic regions of the β1 and β2 subunits contain the box1 and box2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR. IL-12Rβ1 are primarily expressed by activated T cells and NK cells. Experiments with IL-12Rβ1 deficient mice have shown that IL-12Rβ1 is necessary for mouse T and NK cell responsiveness to IL-12 p75. The 114 antibody was generated by immunizing IL-12Rβ1 deficient mice of (129 x BALB/c)F1 background with mouse Ba/F3 cells that were stably transfected with IL-12Rβ1.

BD Pharmingen™ Biotin Mouse Anti-Mouse CD212 - Biotin - Clone 114 - Isotype Mouse IgG2a, κ - Reactivity Ms - 0.1 mg
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen IL-12Rbeta1 Transfected Cell Line
Klon 114
Isotyp IgG2a, kappa
Plasmids, Primers & others

Target Details IL12RB1

Produktdetails anti-IL12RB1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IL12RB1 Antikörper (ABIN2689093) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD212 (IL12RB1 Antibody Abstract)
Hintergrund Synonyms: IL-12 Receptor β1 chain
Pathways JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation

Anwendungsinformationen

Produktdetails anti-IL12RB1 Antikörper Target Details IL12RB1 Handhabung Referenzen für anti-IL12RB1 Antikörper (ABIN2689093) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IL12RB1 Antikörper Target Details IL12RB1 Anwendungsinformationen Referenzen für anti-IL12RB1 Antikörper (ABIN2689093) Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Lagerung 4 °C
Informationen zur Lagerung Store undiluted at 4°C.

Referenzen für anti-IL12RB1 Antikörper (ABIN2689093)

Produktdetails anti-IL12RB1 Antikörper Target Details IL12RB1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Wu, Wang, Gadina, OShea, Presky, Magram: "IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6221-8, 2000

Wang, Wilkinson, Podlaski, Wu, Stern, Presky, Magram: "Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits." in: European journal of immunology, Vol. 29, Issue 6, pp. 2007-13, 1999

Gately, Renzetti, Magram, Stern, Adorini, Gubler, Presky: "The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses." in: Annual review of immunology, Vol. 16, pp. 495-521, 1998

Presky, Minetti, Gillessen, Wilkinson, Wu, Gubler, Chizzonite, Gately: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, 1998

Wu, Ferrante, Gately, Magram: "Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 4, pp. 1658-65, 1997

Presky, Yang, Minetti, Chua, Nabavi, Wu, Gately, Gubler: "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 24, pp. 14002-7, 1997

Chua, Wilkinson, Presky, Gubler: "Cloning and characterization of a mouse IL-12 receptor-beta component." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 9, pp. 4286-94, 1995

Stahl, Yancopoulos: "The alphas, betas, and kinases of cytokine receptor complexes." in: Cell, Vol. 74, Issue 4, pp. 587-90, 1993