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anti-Human HLA-B Antikörper:
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Human Polyclonal HLA-B Primary Antibody für WB - ABIN1944779
Little, Parham: The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens. in Tissue antigens 1992
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Human Polyclonal HLA-B Primary Antibody für WB - ABIN516466
Lorente, García, López: Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. in The Journal of biological chemistry 2011
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demonstrates that individuals who are HLA-B *35:02 carriers are at increased risk of developing minocycline related liver injury
study demonstrated an association between HLA-B*13:01 and dapsone-induced severe cutaneous adverse reactions including Stevens-Johnson syndrome/toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms in nonleprosy patients
This study showed that distinct genetic markers were associated with phenotype-specific PHT-induced severe cutaneous adverse drug reactions. HLA-B*13:01, HLA-B*56:02/04, and CYP2C19 (zeige CYP2C19 Antikörper)*3 were potential genetic markers of phenytoin-induced drug rash with eosinophilia and systemic symptoms/drug hypersensitivity syndrome in Thai patients.
The HLA-DRB1 (zeige HLA-DRB1 Antikörper)*15:01 allele was confirmed to be linked to multiple sclerosis disease in an Italy family.
A total of 39 HLA-A, 66 HLA-B and 47 HLA-DRB1 (zeige HLA-DRB1 Antikörper) alleles were identified.
In white European people, antithyroid drug-induced agranulocytosis was associated with HLA-B*27:05 and with other SNPs on chromosome 6.
Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection
we found for the fi rst time an association between HLA genes and 25OHD concentration. Our results will need to be con fi rmed in a larger sample and preferably with more extensive HLA genotyping (in particular, HLA-A and HLA-C alleles).
These data implicate the prevalent African allele HLA-B*53:01 in the immunopathogenesis of raltegravir-induced DRESS syndrome.
results demonstrate that HIV-1 Nef's inferior ability to downregulate MHC-B compared to that of MHC-A is conserved across primate lentiviruses and suggest that this property influences antiviral cellular immune responses.
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
major histocompatibility complex, class I, B
, HLA class I histocompatibility antigen, B alpha chain
, MHC Class I HLA heavy chain
, MHC HLA-B cell surface glycoprotein
, MHC HLA-B transmembrane glycoprotein
, MHC class I antigen GN00104
, MHC class I antigen HLA-B heavy chain
, MHC class I antigen SHCHA
, leukocyte antigen class I-B
, lymphocyte antigen