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Cardiotrophin-like cytokine factor 1 (CLCF1 (zeige CLCF1 Proteine)) and neuropoietin (NP (zeige CTF2 Proteine)) signalling and their roles in development, adulthood, cancer and degenerative disorders.
CLC plays a role in astrocyte differentiation via STAT3 (zeige STAT3 Proteine) activation within the developing brain
neurotrophin-1/B-cell stimulating factor 3(NNT-1/BSF-3) is expressed in pituitary folliculostellate TtT/GF cells and induced by PKC-, PKA-, and ERK1/2-dependent mechanisms
IL-6 (zeige IL6 Proteine) (gp130 (zeige LRPPRC Proteine)) family cytokine members include CLC/NNT1/BSF3 (zeige CLCF1 Proteine) and IL-27 (zeige IL27 Proteine) [review]
In this study, Clc knockout mice had decreased facial motility, did not suckle, died within 24 hours, and had 32% and 29% fewer motor neurons in the facial nucleus and lumbar ventral horn, respectively.
findings show that galectin-10 functions as a T cell-suppressive molecule in eosinophils
The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation.
CLC and IFNAR1 (zeige IFNAR1 Proteine) were identified to be overall differentially expressed between early- and late-onset CRC (zeige CALR Proteine), and are important in the development of early-onset CRC (zeige CALR Proteine).
DK-PGD (zeige PGD Proteine)-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents
Genetic variation in Charcot-Leyden crystal protein was found to be associated with allergic rhinitis
downregulated significantly in acute myeloid leukemia (zeige BCL11A Proteine) patients whose white blood cell count was higher than 100 x 10(9)/L cells
Changes in the expressions of galectin-10 are potentially important for myeloid cell differentiation into specific lineages.
expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25 (zeige IL2RA Proteine)(+) Treg cells.
Data show that galectin-10 expression was related to the histological grade and with the number of eosinophils in the lesion.
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.
B-cell stimulating factor 3
, cardiotrophin-like cytokine
, novel neurotrophin-1
, Charcot-Leyden crystal protein
, eosinophil lysophospholipase
, galectin 10
, lectin, galactoside-binding, soluble, 10
, lysolecithin acylhydrolase
, Charcot-Leyden crystal protein homolog