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Human FCGR1A Protein expressed in Wheat germ - ABIN1353895
Sakamoto, Ito, Hatanaka, Soni, Mori, Sugimura: Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions. in The Journal of biological chemistry 2009
The neutrophil/lymphocyte ratio is a better addition to C-reactive protein (zeige CRP Proteine) than CD64 index as a marker for infection in COPD (zeige ARCN1 Proteine).
FcgammaRI functions as a regulator for immune inflammation via acceleration of NF-kappaB (zeige NFKB1 Proteine) regulating NLRP3 (zeige NLRP3 Proteine) inflammasome signaling
HIV infection and HIV replication are associated with up-regulation of neutrophil CD64.
Neutrophil CD64 distinguished sepsis and non-septic ICU patients.
These results suggest that tyrosine phosphorylation may be critical in FcgammaRI-dependent endocytosis/phagocytosis that may be regulated by LILRB4 by triggering dephosphorylation of key signalling proteins.
neutrophil CD64 elevated in septic neonates
Neutrophil CD64 expression could be a good predictor as an immune parameter with high sensitivity and a negative predictive value for bacteremia in febrile neutropenic patients.
investigated consequences of 3 nonsynonymous SNPs for FcgammaRI; only SNP V39I reduces immune-complex binding of FcgammaRI whereas monomeric IgG binding is unaffected; SNPs I301M and I338T have no influence on monomeric IgG or immune complex binding, but FcRgamma (zeige FCER1G Proteine) signaling is decreased for both SNPs
Studies show that neutrophil CD64 (nCD64) is a reliable biomarker for diagnosing neonatal sepsis.
Data revealed that Erythema Nodosum Leprosum neutrophils express CD64, presumably contributing to the immunopathogenesis of the disease.
FcgammaRI/FcgammaRIIB expression ratio in splenic macrophages was higher in the Treg-deficient immune thrombocytopenia (ITP (zeige ITPA Proteine)) than in the Treg-deficient non-ITP (zeige ITPA Proteine) and control mice
The IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRI.
Dbn1 regulates systemic anaphylaxis and IgE/Fcgr1-induced degranulation in mast cells by regulating actin reorganization and actin dynamics.
This study demonstrated that the activating FcgammaRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS (zeige GNB5 Proteine).
N-glycans in FcgammaRIa interact with the OmpA of E. coli K1 for inducing disease pathogenesis
observations suggest that IgG-mediated inhibition of fibrocyte differentiation is mediated by FcgammaRs, with FcgammaRI mediating most of the signaling.
Inhibition of GCH1 (zeige GCH1 Proteine) prevented the Escherichia coli K1 induced expression of CD64 in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.
The PI3K inhibitor LY294002 inhibited BCR (zeige BCR Proteine)-mediated, but not TLR-mediated, induction of IkappaB-zeta (zeige NFKBIZ Proteine), consistent with the role of PI3K in BCR (zeige BCR Proteine) signaling and its suppression by FcgammaR.
Dap12 (zeige TYROBP Proteine)- and FcRgamma (zeige FCER1G Proteine)-deficiency exacerbates Granulocyte-Macrophage Colony-Stimulating Factor (zeige CSF2 Proteine)-driven monocyte differentiation and production of inflammatory monocyte-derived dendritic cells.
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.
Fc fragment of IgG, high affinity Ia, receptor for (CD64)
, Fc gamma receptor
, Fc-gamma RI
, Fc-gamma receptor I A1
, IgG Fc receptor I
, fc-gamma RIA
, high affinity immunoglobulin gamma Fc receptor I
, Fc fragment of IgG high affinity Ib receptor
, Fc fragment of IgG, high affinity Ib, receptor for (CD64)
, Fc receptor, IgG, high affinity I
, high affinity IgG Fc receptor, subunit beta
, high-affinity immunoglobulin gamma Fc receptor I
, IgG high affinity Fc receptor
, fc-gamma RI
, igG Fc receptor I
, FCGR1 variant 2
, FCGRI variant 1
, FCGRI variant 3