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Data show that each IgE Fc is targeted by two single-domain antibodies (sdabs) having an epitope largely distinct from the FcepsilonRI (zeige FCER1G Proteine) binding site but overlapping significantly with the CD23-binding site.
Report a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 (zeige TNFRSF14 Proteine) abnormalities, and STAT6 (zeige STAT6 Proteine) mutations.
High CD23 expression is associated with B-cell Lymphoma.
found a higher frequency of LIN1 (zeige CD2BP2 Proteine)(-) CCR3 (zeige CCR3 Proteine)(+) eosinophils, and decreased expression of CD23 and CD62L (zeige SELL Proteine) receptors in eosinophils of AD patients
there is a high CD23a/CD23b ratio of chronic lymphocytic leukemia cells, which demonstrates that in a subset of CLL cases, low CD23 expression together with high CD20 and CD38 expressions may serve as a surrogate for trisomy 12
Binding of CTLA4Fcepsilon to FcepsilonRII/CD23 appeared stronger than that of IgE
Human and murine P2X7 (zeige P2RX7 Proteine) activation induces the rapid shedding of CD23 from B cells, with a potential role for ADAM10 (zeige ADAM10 Proteine) in this process.
Data suggest that the protective immune response involving CD23-IgE-mediated nitric oxide release in cutaneous leishmaniasis (LCL).
Crystal structure of the CD23-Fc3-4 complex with different molecular-packing constraints.
FCER2 polymorphism rs3760687 affects moderately elevated total serum IgE levels, especially in the absence of homozygosity for the risk allele of FCER1A (zeige FCER1A Proteine) SNP rs2427837.
Human and murine P2X7 (zeige P2RX7 Proteine) activation induces the rapid shedding of CD23 (zeige FCER1G Proteine) from B cells, with a potential role for ADAM10 (zeige ADAM10 Proteine) in this process.
CD23 (zeige FCER1G Proteine) was shown to be sorted in an ADAM10 (zeige ADAM10 Proteine)-dependent manner into exosomes.
B cells captured IgE by direct binding to the low-affinity IgE receptor, CD23 (zeige FCER1G Proteine).
After exposure for 10 consecutive days to nebulized ovalbumin (zeige OVA Proteine) challenge, mice with disrupted Fc epsilon RI alpha (zeige FCER1A Proteine) subunit (zeige POLG Proteine) show low response to electrical field stimulation, less airway inflammation and goblet cell hyperplasia, and lower IL-13 (zeige IL13 Proteine) in the lung.
the functions of CD23 splice forms, b and bDelta5, in the apical to basolateral transcytosis of IgE/allergen complexes were investigated
A positive internalization signal for IgE transepithelial transport is localized in the cytoplasmic region shared by all CD23 (zeige FCER1G Proteine) splice forms. This positive signal is negatively regulated by the intracellular CD23b-specific exon.
mechanism by which endogenous B cell activity in vivo is regulated by norepinephrine involves stimulation of the beta2-adrenergic receptor (zeige ADRB2 Proteine) on the B cell alone to increase the level of IgE produced in a p38 MAPK (zeige MAPK14 Proteine)- and soluble CD23 (zeige FCER1G Proteine)-dependent manner
BAFF (zeige TNFSF13B Proteine) does not preferentially induce the expression of CD23 (zeige FCER1G Proteine) or CD21 (zeige CR2 Proteine).
Overall, the data provide a direct demonstration for CD23 (zeige FCER1G Proteine)'s role in regulating IgE production in vivo and suggest that therapies aimed at stabilizing cell surface CD23 (zeige FCER1G Proteine) would be beneficial in controlling allergic disease.
CD23 is an important regulatory factor for IgE production
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Fc receptor alpha multiple ligand receptor
, Fc receptor, IgE, low affinity II, alpha polypeptide
, Fcalpha RII
, Fcalpha muR
, C-type lectin domain family 4, member J
, CD23 antigen
, immunoglobulin E-binding factor
, low affinity immunoglobulin epsilon Fc receptor
, lymphocyte IgE receptor
, FC epsilon RII
, low-affinity IgE receptor