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Hepsin plays a physiologically important role in factor VII (zeige TH Proteine) activation and hemostasis in zebrafish.
Study showed was that Hepsin was downregulated in 78% of gastric cancer. Its high expression seems to predict poor prognosis. These results predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer.
Genetic variation in/near the gene encoding for hepsin protein may influence risk of bipolar disorder and (at least for the rs62122114-A allele) may have functional impact (i.e. differential expression) as evidenced by serum HPN protein expression.
significant negative association was found between hepsin expression in endometrial carcinoma cases regarding the grade and the size of tumors as well as myometrial invasion
These data demonstrate that the membrane-bound serine protease hepsin is the enzyme responsible for the physiological cleavage of uromodulin (zeige UMOD Proteine).
The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1 (zeige SPINT1 Proteine), events which together trigger gain-of-function activity impacting HGF (zeige HGF Proteine)/MET signalling and epithelial cohesion
The Hepsin pathway acts in concert with Wnt (zeige WNT2 Proteine) pathway to promote prostate cancer progression.
Low expression levels of hepsin and TMPRSS3 (zeige TMPRSS4 Proteine) are associated with poor breast cancer survival
Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR (zeige P2RY4 Proteine) expression and eIF-2alpha (zeige EIF2S1 Proteine) phosphorylation.
The results of this study suggest that, in Korean men, some polymorphisms in the HPN gene might be associated with the risk of developing prostate cancer.
hepsin expression is frequently up-regulated in breast cancer tissues, which is associated with tumor growth and progression
crystal structure of human hepsin, confirming cleavage and association of the two chains
Hepsin cooperates with MYC (zeige MYC Proteine) in the progression of adenocarcinoma in a prostate cancer mouse model.
Results suggest that upregulation of the cell surface serine protease hepsin in a primary tumor promotes cancer progression and metastasis.
the ability of hepsin to efficiently activate pro-uPA (zeige PLAU Proteine) suggests that it may initiate plasmin (zeige PLG Proteine)-mediated proteolytic pathways at the tumor/stroma interface that lead to basement membrane disruption and tumor progression
Hearing impairment present in hepsin/Tmprss1-null mice is characterized by a combination of various structural, cellular, and molecular abnormalities that are likely to affect different cochlear processes.
The ability of ectopic hepsin to induce tumor growth in mice is abrogated by the mutation of 3 critical residues in the catalytic domain, thus implicating the enzymatic activity of hepsin in promoting tumor progression.
Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility.
This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
hepsin (transmembrane protease, serine 1)
, serine protease hepsin
, Serine protease hepsin
, transmembrane protease serine 1
, transmembrane protease, serine 1