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This study identified histone modification by SUMO as the first post-translational modification that stimulates intranucleosomal demethylation by the developmentally critical LSD1 (zeige KDM1A Proteine)-CoREST complex.
results demonstrate that CoREST and LSD1 (zeige KDM1A Proteine) downregulate the Notch (zeige NOTCH1 Proteine) pathway in the developing cerebral cortex
ERalpha (zeige ESR1 Proteine) engages not only LSD1 (zeige KDM1A Proteine), but its partners of the CoREST corepressor complex and the molecular chaperone (zeige HSP90AA1 Proteine) Hsp90 (zeige HSP90 Proteine).
Expressions of REST and RCOR1 genes may downregulate SYN1 (zeige SYN1 Proteine) expression in gliomas.
Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.
Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.
The results suggest that LSD1 (zeige KDM1A Proteine)/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.
results suggest that LSD1 (zeige KDM1A Proteine)-CoREST functions as an ergonomic clamp (zeige PDZK1 Proteine) that induces the detachment of the H3 histone (zeige HIST1H3B Proteine) tail from the nucleosomal DNA to make it available for capture by the enzyme active site.
Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients.
RXR interaction is necessary for NPM (zeige NPM1 Proteine)-RAR (zeige RARA Proteine)-mediated myeloid maturation arrest.
In mature erythroid cells, a strong upsurge in Rcor3 (zeige RCOR3 Proteine) and a sharp decline in Rcor1 (zeige Rcor2 Proteine) levels counteract LSD1 (zeige KDM1A Proteine)/Rcor1 (zeige Rcor2 Proteine)/2-mediated differentiation.
Rcor1 (zeige Rcor2 Proteine) promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
MHC class I promoter binding protein
, nuclear receptor subfamily 2 group B member 2
, retinoic acid receptor RXR-beta
, REST corepressor 1
, Mtfp1-like proline rich protein
, REST corepressor 1-like