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anti-Human CoREST Antikörper:
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Mammalian Monoclonal CoREST Primary Antibody für ISt, IHC - ABIN1304608
Sáez, Gómez, Barrios, Parada, Galdames, González, Andrés: Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation. in PLoS ONE 2015
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Human Polyclonal CoREST Primary Antibody für IHC, WB - ABIN2780965
Battaglioli, Andrés, Rose, Chenoweth, Rosenfeld, Anderson, Mandel: REST repression of neuronal genes requires components of the hSWI.SNF complex. in The Journal of biological chemistry 2002
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This study showed that tetrahydrofolate stably binds to the LSD1/CoREST complex, in its open conformation, at its entrance.
the intact CoREST complex is targeted with dual histone deacetylase and demethylase inhibitors
This study identified histone modification by SUMO as the first post-translational modification that stimulates intranucleosomal demethylation by the developmentally critical LSD1-CoREST complex.
results demonstrate that CoREST and LSD1 downregulate the Notch pathway in the developing cerebral cortex
ERalpha engages not only LSD1, but its partners of the CoREST corepressor complex and the molecular chaperone Hsp90.
Expressions of REST and RCOR1 genes may downregulate SYN1 expression in gliomas.
Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.
The results suggest that LSD1/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.
results suggest that LSD1-CoREST functions as an ergonomic clamp that induces the detachment of the H3 histone tail from the nucleosomal DNA to make it available for capture by the enzyme active site.
Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients.
a combination of virtual screening and biological approaches can lead to compounds reducing REST complex formation
Data show that miR-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 and HDAC4 mRNAs.
Gfi-1B p32 isoform binds to Gfi-1B target gene promoters and associates with the LSD1-CoREST repressor complex more efficiently than the major Gfi-1B p37 isoform
the H3 binding pocket is a central target site to (i) switch off LSD1 amino oxidase activity, thus H3-tail demethylation; (ii) block the competitive binding of transcription factors; and (iii) prevent chromatin anchoring to LSD1/CoREST.
The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes.
Transciption factor SNAIL1 mimics the histone H3 tail and binds to the histone demethylase LSD1-transcription co-repressor (CoREST) complex. The crystal structure of the complex is given here.
Insight into the molecular basis of the interaction between scaffolding protein CoREST and histone deacetylase LSD1 may suggest a new means of inhibiting LSD1 activity by misdirecting the enzyme away from nucleosomal substrates.
silencing of CoREST by siRNA transfection in normal articular cartilage may reflect CoREST repression in advanced osteoarthritic cartilage, which results in phenotypic genes modulation and suggests a homeostatic role of this transcription factor
CoREST does not play an influential role in regulating HSV-1 infection.
PC4 interacts with heterochromatin protein 1alpha, REST/NRSF (RE1-silencing transcription factor/neuron-restrictive silencer factor) and CoREST to establish the repressed state of neural genes in nonneuronal cells.
An INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development.
In mature erythroid cells, a strong upsurge in Rcor3 and a sharp decline in Rcor1 levels counteract LSD1/Rcor1/2-mediated differentiation.
Rcor1 promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).
REST corepressor 1
, Mtfp1-like proline rich protein
, REST corepressor 1-like