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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN2017696
Sampath, Coughlin, Whetstone, Banach, Corbett, Ridge, Ozkaynak, Oppermann, Rueger: Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. in The Journal of biological chemistry 1990
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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1589575
Suliman, Xing, Wu, Xue, Pedersen, Sun, Døskeland, Nickel, Waag, Lygre, Finne-Wistrand, Steinmüller-Nethl, Krueger, Mustafa: Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo. in Journal of controlled release : official journal of the Controlled Release Society 2014
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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN413080
Sharapova, Kotnova, Galushkina, Lavrova, Poletaeva, Tukhvatulin, Tukhvatullin, Semikhin, Gromov, Soboleva, Ershova, Za?tsev, Sergienko, Lunin, Kariagina: [Production of the recombinant human bone morphogenetic protein-2 in Escherichia coli and testing of its biological activity in vitro and in vivo]. in Molekuliarnaia biologiia 2011
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Human BMP2 Protein expressed in Escherichia coli (E. coli) - ABIN2002823
Wozney, Rosen, Celeste, Mitsock, Whitters, Kriz, Hewick, Wang: Novel regulators of bone formation: molecular clones and activities. in Science (New York, N.Y.) 1989
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Synergistic effects of BMP-2, BMP-6 (zeige BMP6 Proteine) or BMP-7 (zeige BMP7 Proteine) with human plasma fibronectin (zeige FN1 Proteine) onto hydroxyapatite coatings.
High-dose recombinant human bone morphogenetic protein-2 impacts histological and biomechanical properties of a cervical spine fusion segment: results from a sheep model.
Report osteoblast-like transformation of epithelial breast cancer cells that have undergone epithelial-mesenchymal transition followed by bone morphogenetic protein-2 stimulation. RUNX2 (zeige RUNX2 Proteine) functions as a master mediator of this process.
BMP2-transduced BMSCs can maintain the chondrocyte-like phenotype in PRP (zeige C4BPA Proteine) gel in vitro, and the combined use of these two agents can significantly promote repair of the degenerated discs in vivo
these results suggest that the BMP2 gene polymorphism may be related to the development of allograft rejection and graft dysfunction in kidney transplant recipients
Data show that the GREMLIN 2 (GREM2 (zeige GREM2 Proteine)) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes.
Results identify a novel 4671-bp tandem duplication downstream of BMP2, which is associated with brachydactyly type A2 . The duplication highly overlaps the sequences reported previously but has a different breakpoint and a different flanking microhomology.
miR (zeige MLXIP Proteine)-106b inhibited osteoblastic differentiation and bone formation partly through directly targeting bone morphogenetic protein 2.
BMP2 decreases gap junction intercellular communication of luteinized human granulosa cells by downregulating Cx43 (zeige GJA1 Proteine) expression through an ALK2 (zeige ACRV1 Proteine)/ALK3 (zeige BMPR1A Proteine)-mediated SMAD (zeige SMAD1 Proteine)-dependent signaling pathway.
BMP2 also requires Src (zeige SRC Proteine) for filamentous actin polymerization in Tgfbr3 (zeige TGFBR3 Proteine)(-/-) epicardial cells.
BMP2 may induce osteogenic differentiation.
Increased bone mass in Crmp4 (zeige DPYSL3 Proteine)(-/-) mice was associated with enhanced BMP2 signaling and BMP2-induced osteoblast differentiation in Crmp4 (zeige DPYSL3 Proteine)(-/-) osteoblasts (OBs (zeige LEP Proteine)).
High BMPR2 (zeige BMPR2 Proteine) expression is associated with aberrant synaptic development in mouse and Drosophila models of Fragile X (zeige FMR1 Proteine) syndrome.
BMPR2 (zeige BMPR2 Proteine) deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6 (zeige BMP6 Proteine)-driven prostate cancer progression
Deletion of the "ultra-conserved sequence" within the 3'UTR of the Bmp2 was associated with elevated Bmp2 mRNA and BMP signaling levels, reduced fitness, and embryonic malformations.
Dual luciferase report assay verified that miR (zeige MLXIP Proteine)-3065-5p could bind to the 3'UTR of bone morphogenetic protein receptor type II (BMPR2 (zeige BMPR2 Proteine)), which dramatically increased in the beginning of odontoblastic differentiation but decreased in the terminal differentiation stage.
increased BMPR2 (zeige BMPR2 Proteine) signal transduction is linked to fragile X (zeige FMR1 Proteine) syndrome (FXS) and that the BMPR2 (zeige BMPR2 Proteine)-LIMK1 (zeige LIMK1 Proteine) pathway is a putative therapeutic target in patients with FXS and possibly other forms of autism
cells stimulated with BMP-2 in the presence of FBS (zeige FBS Proteine) require the phosphorylation of Akt (zeige AKT1 Proteine) at Ser473 and the dephosphorylation of Akt (zeige AKT1 Proteine) at Thr308 to increase the osteoblast differentiation with alkaline phosphatase activity similar to that of BMP-9 (zeige GDF2 Proteine) plus FBS (zeige FBS Proteine).
This study showed that release of BMP-2 and SDF-1alpha from heparinized MCM scaffolds allows for the reduction of the applied BMP-2 concentration since SDF-1alpha seems to enhance the osteoinductive potential of BMP-2.
Bone morphogenetic protein inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation
High BMP2 expression is associated with cystic ovarian disease.
both FSH (zeige BRD2 Proteine) and BMP-2 reduced follicular mRNA expression of GDF9 (zeige GDF9 Proteine) and NLRP5 when compared to follicles cultured in media containing only FSH (zeige BRD2 Proteine)
The BMP2/4 (zeige BMP4 Proteine) ligand and receptor system presides within bovine trophectoderm prior to uterine attachment.
concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than oocyte maturation
The transfecting capability of a BMP-2 specific vector is examined and supports the idea that BMP-2 might diminish osseointegration and implant fixation.
While BMP2 expression begins at (pregastrulation) stage 1 in the hypoblast, BMP4 (zeige BMP4 Proteine) expression commences--distinctly delayed compared to the mouse--diffusely at (pregastrulation) stage 2; from stage 3 onwards.
Maxillary sinus floor elevation using BMP-2 gene-modified bone marrow stromal cells and TCP in rabbits
Data show that BMP-2, BMP-4 (zeige BMP4 Proteine), and BMP-7 (zeige BMP7 Proteine), noggin (zeige NOG Proteine), and chordin (zeige CHRD Proteine) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
BMP2 is not suitable to regenerate osteochondral lesions completely
High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-beta1 (zeige TGFB1 Proteine).
Report temporal regulation of BMP2 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential induction of BMP2.
The effects of soy- and cow's milk-based formulas compared to nursing on bone development through BMP2 expression in neonatal pigs are reported.
The effect of bone morphogenetic protein (BMP) 12 and BMP2 expression on differentiation of bone marrow-derived mesenchymal stem cells and superficial digital flexor tenocytes is reported.
Study found that BMP-2 (zeige BMP4 Proteine) is negatively regulated by miR (zeige MYLIP Proteine)-140 during early embryogenesis and bone development in zebra fi sh.
Structures of Bmp2a, Bmp2b (zeige BMP4 Proteine), Bmp4 (zeige BMP4 Proteine) and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.
bmp2a is a crucial player in the specification of the ventral pancreatic bud in zebrafish embryos.
results indicate that both the induction of a photoreceptor fate and the interaction with Notch (zeige NOTCH1 Proteine) relies on a canonical BMP/Smad5 (zeige SMAD5 Proteine) pathway
Mypt1 (zeige PPP1R12A Proteine) mediates coordination between mesoderm and endoderm cell movements in order to carefully position the liver primordium such that it receives a Bmp2 (zeige BMP4 Proteine) signal that is essential for liver formation
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.
, bone morphogenetic protein 2A
, BMP type II receptor
, BMP type-2 receptor
, bone morphogenetic protein receptor type-2
, bone morphogenic protein receptor, type II (serine/threonine kinase)
, bone morphogenetic protein 2 B
, bone morphogenetic protein 2-B
, bone morphogenetic protein 2
, Bone morphogenetic protein 2
, bone morphogenetic protein 2-like
, bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A)